Gokirmak Munire, Yildirim Zeki, Canan Hasanoglu H, Koksal Nurhan, Mehmet Nihayet
Department of Pulmonary Diseases, Inonu University, Turgut Ozal Medical Center, 44069, Malatya, Turkey.
Clin Chim Acta. 2003 May;331(1-2):119-26. doi: 10.1016/s0009-8981(03)00117-7.
We previously showed that apricot sulfurization workers (ASW) are exposed to high concentrations of SO(2), resulting in an asthma-like syndrome. The aim of this study was to evaluate whether oxidative stress plays a role in the pathogenesis of asthma-like syndrome due to the high concentrations of SO(2) exposure in agricultural environment.
Serum antioxidant enzyme activities and malondialdehyde (MDA) concentrations, which are markers of lipid peroxidation, and pulmonary function tests (PFT) were measured in 40 volunteer ASW and compared to 20 healthy control subjects.
The superoxide dismutase (SOD, 2.2+/-0.6 vs. 3.2+/-0.7 U/ml), glutathione peroxidase (GSH-Px, 0.6+/-0.3 vs. 1.1+/-0.3 U/ml) and catalase (107.6+/-27.4 vs. 152.6+/-14.3 k/l) activities in ASW were significantly (p<0.0001) lower than controls, whereas the malondialdehyde concentration (4.1+/-0.9 vs. 1.9+/-5.3 nmol/l) was higher in ASW (p<0.0001). ASW had significant decreases in pulmonary function parameters after exposure.
These results show that occupational exposure to high concentrations of SO(2) enhances oxidative stress and lipid peroxidation may be considered as a new mechanism of SO(2)-induced bronchoconstriction.
我们之前发现，杏硫化工人（ASW）暴露于高浓度的二氧化硫中，会引发类似哮喘的综合征。本研究旨在评估在农业环境中，高浓度二氧化硫暴露导致的氧化应激是否在类似哮喘综合征的发病机制中起作用。
对40名志愿ASW测量血清抗氧化酶活性、脂质过氧化标志物丙二醛（MDA）浓度以及肺功能测试（PFT），并与20名健康对照受试者进行比较。
ASW的超氧化物歧化酶（SOD，2.2±0.6对3.2±0.7 U/ml）、谷胱甘肽过氧化物酶（GSH-Px，0.6±0.3对1.1±0.3 U/ml）和过氧化氢酶（107.6±27.4对152.6±14.3 k/l）活性显著低于对照组（p<0.0001），而ASW的丙二醛浓度（4.1±0.9对1.9±5.3 nmol/l）更高（p<0.0001）。暴露后，ASW的肺功能参数显著下降。
这些结果表明，职业性暴露于高浓度二氧化硫会增强氧化应激，脂质过氧化可能被视为二氧化硫诱导支气管收缩的新机制。
