Yildirim Zeki, Kilic Talat, Koksal Nurhan, Kotuk Mahir
Inonu University, Faculty of Medicine, Turgut Ozal Medical Center, Departments of Pulmonary Diseases, Malatya 44069, Turkey.
Pharmacol Res. 2005 May;51(5):479-82. doi: 10.1016/j.phrs.2004.12.004.
We previously showed that apricot sulfurization workers are exposed to high concentrations of sulfur dioxide (SO2), resulting in an asthma-like syndrome. The aim of this study was to investigate whether pre-treatment of ipratropium bromide protects bronchoconstriction induced by SO2 exposure during apricot sulfurization processes that causes asthma-like syndrome. Firstly, pulmonary function tests were measured before and immediately after SO2 exposure due to processes of apricot sulfurization in 21 healthy volunteer apricot sulfurization workers who did not use any medication in apricot farms. One week later, same measurements were repeated in the same workers when they were working in same farm but they were administered two puffs of ipratropium bromide (20 microg per dose) before 30 min second SO2 exposure for protection of SO2-induced bronchoconstriction. Occupational SO2 exposure caused significant decrement in forced vital capacity (FVC), forced expiratory volume (FEV1) and forced mid-expiratory flow rate (FEF25-75%) in the worker and these decrements were prevented by ipratropium bromide given 30 min before SO2 exposure. This result suggests that pre-treatment of ipratropium bromide protects SO2-induced bronchoconstriction in healthy worker during apricot sulfurization processes that causes asthma-like syndrome in agricultural environment.
我们之前发现，杏子硫化工人暴露于高浓度的二氧化硫（SO₂）中，会引发类似哮喘的综合征。本研究的目的是调查异丙托溴铵预处理是否能保护在杏子硫化过程中因接触SO₂而导致类似哮喘综合征的支气管收缩。首先，对21名在杏园未使用任何药物的健康志愿者杏子硫化工人，在杏子硫化过程中接触SO₂之前和之后立即进行肺功能测试。一周后，同样的工人在同一农场工作时重复进行相同测量，但在第二次接触SO₂前30分钟给予两喷异丙托溴铵（每剂20微克）以保护SO₂诱导的支气管收缩。职业性SO₂暴露导致工人的用力肺活量（FVC）、用力呼气量（FEV₁）和用力呼气中期流速（FEF₂₅₋₇₅%）显著下降，而在SO₂暴露前30分钟给予异丙托溴铵可预防这些下降。这一结果表明，在导致农业环境中类似哮喘综合征的杏子硫化过程中，异丙托溴铵预处理可保护健康工人免受SO₂诱导的支气管收缩。
