Calvey T N, Williams N E, Muir K T, Barber H E
Clin Pharmacol Ther. 1976 Jun;19(6):813-20. doi: 10.1002/cpt1976196813.
The plasma concentration of edrophonium was measured in man after intravenous administration. In 5 patients, the clearance of edrophonium from the circulation during the 1-hr period of sampling was invariably resolved into 2 exponential components. An initial rapid phase of elimination from plasma (T/2 = 0.54 TO 1.92 Min) was followed by a much slower decline (T/2 = 24.23 to 45.00 Min), corresponding to the fall in concentration between 10 and 60 min. In parallel experiments in the rat, the clearance of 14C-edrophonium was resolved into 3 exponential components, although the final component could not be reliably defined until 1 to 3 hr after intravenous injection. It is suggested that the rapid fall in the plasma concentration of edrophonium in both species is not dependent on metabolism or excretion, but is due to the rapid uptake of the drug by the liver and kidneys.
静脉注射后，在人体中测量了依酚氯铵的血浆浓度。在5名患者中，在1小时采样期间依酚氯铵从循环中的清除率始终分解为2个指数成分。血浆中最初的快速消除期（T/2 = 0.54至1.92分钟）之后是慢得多的下降（T/2 = 24.23至45.00分钟），对应于10至60分钟之间的浓度下降。在大鼠的平行实验中，14C-依酚氯铵的清除率分解为3个指数成分，尽管直到静脉注射后1至3小时才能可靠地确定最终成分。有人提出，两种物种中依酚氯铵血浆浓度的快速下降不依赖于代谢或排泄，而是由于肝脏和肾脏对药物的快速摄取。
