依酚氯铵对大鼠红细胞乙酰胆碱酯酶及神经肌肉功能的影响
The effect of edrophonium on erythrocyte acetylcholinesterase and neuromuscular function in the rat.
作者信息
Barber H E, Calvey T N, Muir K T, Taylor K
出版信息
Br J Pharmacol. 1976 Jan;56(1):93-9. doi: 10.1111/j.1476-5381.1976.tb06963.x.
Abstract
- The relation between the concentration of edrophonium in plasma, inhibition of red cell acetylcholinesterase, and neuromuscular transmission was studied in the rat. 2. In both in vivo and in vitro conditions, red cell acetylcholinesterase activity was predictably related to the concentration of the quaternary amine. 3. After low doses of edrophonium (1.0 mumol/kg) there was a significant correlation between the monophasic potentiation of twitch tension and the plasma concentration of the drug. In contrast, with higher doses of edrophonium (4.0 or 10.0 mumol/kg) a biphasic potentiation of twitch tension was observed; this was only correlated with the plasma concentration of the drug during the secondary decline in neuromuscular facilitation. Subsequent recovery of normal neuromuscular transmission invariably occurred at a constant plasma concentration of edrophonium.
摘要
- 在大鼠中研究了血浆中依酚氯铵浓度、红细胞乙酰胆碱酯酶抑制与神经肌肉传递之间的关系。2. 在体内和体外条件下，红细胞乙酰胆碱酯酶活性均可预测地与季铵盐浓度相关。3. 给予低剂量依酚氯铵（1.0 μmol/kg）后，单次抽搐张力增强与药物血浆浓度之间存在显著相关性。相比之下，给予较高剂量依酚氯铵（4.0或10.0 μmol/kg）时，观察到抽搐张力呈双相增强；这仅在神经肌肉易化的二次下降期间与药物血浆浓度相关。正常神经肌肉传递的随后恢复总是在依酚氯铵的恒定血浆浓度下发生。
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The effect of edrophonium on erythrocyte acetylcholinesterase and neuromuscular function in the rat.依酚氯铵对大鼠红细胞乙酰胆碱酯酶及神经肌肉功能的影响
Br J Pharmacol. 1976 Jan;56(1):93-9. doi: 10.1111/j.1476-5381.1976.tb06963.x.
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引用本文的文献
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Pharmacodynamic analysis of contractile potentiation by cholinesterase inhibitors in rats.大鼠体内胆碱酯酶抑制剂对收缩增强作用的药效学分析
J Pharmacokinet Biopharm. 1996 Aug;24(4):327-48. doi: 10.1007/BF02353516.
2
The relationship between the pharmacokinetics, cholinesterase inhibition and facilitation of twitch tension of the quaternary ammonium anticholinesterase drugs, neostigmine, pyridostigmine, edrophonium and 3-hydroxyphenyltrimethylammonium.季铵类抗胆碱酯酶药物新斯的明、吡啶斯的明、依酚氯铵和3-羟基苯基三甲基铵的药代动力学、胆碱酯酶抑制作用与抽搐张力增强之间的关系。
Br J Pharmacol. 1979 Aug;66(4):525-30. doi: 10.1111/j.1476-5381.1979.tb13690.x.
本文引用的文献
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The mechanism of anticurare action of certain neostigmine analogues.某些新斯的明类似物的抗箭毒作用机制。
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The pharmacology of anti-curare agents.抗箭毒剂的药理学。
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Anticurare action of phenolic quaternary ammonium salts.酚季铵盐的抗箭毒作用。
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A comparison between the effects of edrophonium and choline in the skeletal muscles of the cat.依酚氯铵与胆碱对猫骨骼肌作用的比较。
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The interaction between edrophonium (tensilon) and acetylcholine at the motor end-plate.依酚氯铵（腾喜龙）与乙酰胆碱在运动终板处的相互作用。
Br J Pharmacol Chemother. 1957 Jun;12(2):260-4. doi: 10.1111/j.1476-5381.1957.tb00131.x.
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The interaction of tensilon and neostigmine with acetylcholinesterase.腾喜龙和新斯的明与乙酰胆碱酯酶的相互作用。
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Excretion of 14 C-edrophonium and its metabolites in bile: role of the liver cell and the peribiliary vascular plexus.14C-依酚氯铵及其代谢产物在胆汁中的排泄：肝细胞和胆小管周围血管丛的作用。
Br J Pharmacol. 1972 Mar;44(3):534-43. doi: 10.1111/j.1476-5381.1972.tb07290.x.
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The removal of 14 C-edrophonium from the circulation.14C-依酚氯铵从循环系统中的清除。
Br J Pharmacol. 1972 Oct;46(2):355-7. doi: 10.1111/j.1476-5381.1972.tb06882.x.
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Microphysiology of vertebrate neuromuscular transmission.脊椎动物神经肌肉传递的微观生理学
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Electrophysiological estimation of inhibition of acetylcholinesterase with normal transmitter release.在递质正常释放情况下对乙酰胆碱酯酶抑制作用的电生理评估。
J Physiol. 1971 Oct;218 Suppl:66P-67P.
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