镰状细胞病中的疼痛、情绪与阿片类药物使用

Pain, mood and opioid medication use in sickle cell disease.

作者信息

Anie Kofi A, Steptoe Andrew

机构信息

Imperial College School of Medicine, Brent Sickle Cell and Thalassaemia Center, Central Middlesex Hospital, London, UK.

出版信息

Hematol J. 2003;4(1):71-3. doi: 10.1038/sj.thj.6200227.

DOI:10.1038/sj.thj.6200227

PMID:12692524

Abstract

Patients with sickle cell disease show wide variations in their experience of pain, and in the impact of pain on everyday functioning. This study examined relations between pain, mood, physical activity, and medication use in a longitudinal naturalistic self-monitoring study of 21 adult sickle cell patients over 12 months. Results suggest that opioid medication use is related to the impact of pain on daily life. Patients who use opioids more frequently for sickle cell pain show more disruption of their lives, with reduced activity levels and more pessimistic mood.

摘要

镰状细胞病患者在疼痛体验以及疼痛对日常功能的影响方面存在很大差异。本研究在一项对21名成年镰状细胞病患者进行的为期12个月的纵向自然主义自我监测研究中，考察了疼痛、情绪、身体活动和药物使用之间的关系。结果表明，阿片类药物的使用与疼痛对日常生活的影响有关。因镰状细胞疼痛而更频繁使用阿片类药物的患者，其生活受到的干扰更大，活动水平降低，情绪更消极。