Anie Kofi A, Grocott Hannah, White Lauren, Dzingina Mendwas, Rogers Gabriel, Cho Gavin
Haematology and Sickle Cell Centre, Central Middlesex Hospital, London, UK.
BMJ Open. 2012 Jul 2;2(4). doi: 10.1136/bmjopen-2012-001274. Print 2012.
Acute pain is a hallmark of sickle cell disease (SCD) for which frequent hospital admissions may be required, affecting the quality of life of patients.
To characterise the relationship between adult patient self-reported sickle cell pain, mood and quality of life during and after hospital admissions.
Longitudinal study across three time-points.
Secondary care, single specialist sickle cell centre.
510 adult patients with SCD admitted to hospital daycare or inpatient units.
Self-assessments of pain, mood and health-related quality of life with health utility (measured on the EQ-5D) on admission, before discharge and at 1-week postdischarge.
Mood, general health and quality of life showed significant steady improvements with reduction of pain in patients with SCD on admission to hospital, before discharge and at 1-week follow-up (p<0.01). Health utility scores derived from the EQ-5D showed a negative association with pain in regression analysis over the three time-points.
Examining health-related quality of life and health utility in relation to pain during hospital admissions is valuable in terms of targeting appropriate psychological interventions within the context of a multidisciplinary approach to managing sickle cell pain. This has implications for healthcare costs.
急性疼痛是镰状细胞病（SCD）的一个特征，为此可能需要频繁住院，这会影响患者的生活质量。
描述成年患者自我报告的镰状细胞疼痛、情绪与住院期间及出院后生活质量之间的关系。
在三个时间点进行的纵向研究。
二级医疗，单一专科镰状细胞中心。
510名入住医院日间护理或住院病房的成年SCD患者。
在入院时、出院前和出院后1周，采用健康效用（通过EQ-5D测量）对疼痛、情绪和与健康相关的生活质量进行自我评估。
在入院时、出院前和1周随访时，SCD患者的情绪、总体健康状况和生活质量随着疼痛减轻而显著稳步改善（p<0.01）。在三个时间点的回归分析中，EQ-5D得出的健康效用评分与疼痛呈负相关。
在多学科方法管理镰状细胞疼痛的背景下，研究住院期间与疼痛相关的健康相关生活质量和健康效用，对于确定适当的心理干预措施具有重要价值。这对医疗成本有影响。
