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我们是否应该进行更多的造血干细胞联合实体器官移植?

Should we be performing more combined hematopoietic stem cell plus solid organ transplants?

作者信息

Chiang K Y, Lazarus H M

机构信息

Division of Pediatric Hematology/Oncology, Children's Healthcare of Atlanta, GA 30322, USA.

出版信息

Bone Marrow Transplant. 2003 Apr;31(8):633-42. doi: 10.1038/sj.bmt.1703952.

DOI:10.1038/sj.bmt.1703952
PMID:12692602
Abstract

Both bone marrow and solid organ transplants (SOTs) can be life saving for a wide variety of diseases. We reviewed the literature and summarized the experiences of dual transplants. In total, 37 patients received a SOT for organ failure after a previous hematopoietic stem cell transplant. In all, 12 subjects received SOTs followed by a bone marrow transplant, while three patients received simultaneous SOTs and bone marrow transplants. Of these 52 patients, 37 were alive at the time of the original report at follow-up times ranging from 3 months to 8 years. A special registry for data collection may prove helpful for obtaining long-term follow-up data and providing outcome information that may improve future patient survival.

摘要

骨髓移植和实体器官移植(SOT)对于多种疾病都可能挽救生命。我们回顾了文献并总结了双重移植的经验。共有37例患者在先前的造血干细胞移植后因器官衰竭接受了实体器官移植。总共有12名受试者接受了实体器官移植,随后进行了骨髓移植,而3名患者同时接受了实体器官移植和骨髓移植。在这52例患者中,在原始报告时,37例存活,随访时间为3个月至8年。一个专门的数据收集登记处可能有助于获得长期随访数据,并提供可能改善未来患者生存率的结果信息。

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Should we be performing more combined hematopoietic stem cell plus solid organ transplants?我们是否应该进行更多的造血干细胞联合实体器官移植?
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引用本文的文献

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Bone Marrow Transplant. 2019 Feb;54(2):190-203. doi: 10.1038/s41409-018-0255-9. Epub 2018 Aug 6.
2
Toward dual hematopoietic stem-cell transplantation and solid-organ transplantation for sickle-cell disease.针对镰状细胞病的双造血干细胞移植和实体器官移植。
Blood Adv. 2018 Mar 13;2(5):575-585. doi: 10.1182/bloodadvances.2017012500.
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Hemophagocytic lymphohistiocytosis presenting in a pediatric patient with near total colonic and small bowel aganglionosis: a case report.
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J Med Case Rep. 2017 Aug 31;11(1):244. doi: 10.1186/s13256-017-1390-4.
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Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective.造血嵌合体诱导耐受的机制:免疫观点。
Stem Cells Transl Med. 2017 Mar;6(3):700-712. doi: 10.1002/sctm.16-0358. Epub 2017 Jan 3.
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Clinical operational tolerance after renal transplantation: current status and future challenges.肾移植后临床操作性耐受:现状与未来挑战。
Ann Surg. 2010 Dec;252(6):915-28. doi: 10.1097/SLA.0b013e3181f3efb0.
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