二氯二苯三氯乙烷（DDT）促进黄曲霉毒素B1诱导的肝癌发生。

Promotion of aflatoxin B1-induced hepatocarcinogenesis by dichlorodiphenyl trichloroethane (DDT).

作者信息

Angsubhakorn Subhkij, Pradermwong Apichat, Phanwichien Kanthimani, Nguansangiam Sudarat

机构信息

Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.

出版信息

Southeast Asian J Trop Med Public Health. 2002 Sep;33(3):613-23.

PMID:12693600

Abstract

A study of the effect in rats of dichlorodiphenyl trichloroethane (DDT) on hepatocarcinogenesis that is initated by aflatoxin B1 (AFB1). In the first experiment, Buffalo rats were given a single oral dose of AFB1 (5 mg/kg) followed by dietary DDT (100 ppm) for 20 weeks. Neoplastic nodules were observed in 1 of the 14 AFB1-exposed rats, compared with 3 of the 19 rats in the AFB1/DDT group. In the second experiment, Wistar rats were given dietary aflatoxin B, (4 ppm) for 6 weeks followed by a 6-week exposure to DDT (500 ppm) in a plain semisynthetic diet. Five altered hepatic foci were displayed by seven rats in the AFB1 group, compared with 6 foci and one neoplastic focus in five of the AFB1/DDT rats at 32 weeks. Subsequently, the AFB1 group produced 8 (27.5%) tumor-bearing rats while 10 of the 28 (35.7%) AFB1/DDT-exposed rats were tumor-bearing by 60 weeks. The results suggest that DDT slightly potentiates hepatocarcinogenesis induced by either a single dose of AFB1 or short term-dietary AFB1.

摘要

一项关于二氯二苯三氯乙烷（DDT）对黄曲霉毒素B1（AFB1）引发的大鼠肝癌发生影响的研究。在第一个实验中，给布法罗大鼠单次口服剂量的AFB1（5毫克/千克），随后在饮食中添加DDT（100 ppm），持续20周。在14只暴露于AFB1的大鼠中，有1只观察到肿瘤结节，而在AFB1/DDT组的19只大鼠中有3只观察到肿瘤结节。在第二个实验中，给Wistar大鼠在饮食中添加黄曲霉毒素B1（4 ppm），持续6周，随后在普通半合成饮食中暴露于DDT（500 ppm）6周。在32周时，AFB1组的7只大鼠中有5个肝脏病灶发生改变，而AFB1/DDT组的5只大鼠中有6个病灶和1个肿瘤病灶。随后，到60周时，AFB1组产生了8只（27.5%）患肿瘤大鼠，而在28只暴露于AFB1/DDT的大鼠中有10只（35.7%）患肿瘤。结果表明，DDT对单次剂量AFB1或短期饮食中AFB1诱导的肝癌发生有轻微的促进作用。