Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Int J Cancer. 2012 Nov 1;131(9):2078-84. doi: 10.1002/ijc.27459. Epub 2012 Mar 15.
Dichlorodiphenyltrichloroethane (p,p'-DDT), an organochlorine pesticide known to have deleterious health effects in humans, has been linked to hepatocellular carcinoma (HCC) in rodents. A recent study has reported that p,p'-DDT and its most persistent metabolite, dichlorodiphenyldichloroethylene (p,p'-DDE), may also be associated with HCC in humans. To examine whether there is an association between p,p'-DDT and/or p,p'-DDE in a population at high-risk of developing HCC, a nested case-control study was conducted within the 83,794 person Haimen City Cohort in China. Sera and questionnaire data were collected from all participants between 1992 and 1993. This study included 473 persons who developed HCC and 492 who did not, frequency matched on sex, age and area of residence. p,p'-DDT and p,p'-DDE levels were determined by mass spectrometry. Hepatitis B viral infection status (based on hepatitis B virus surface antigen; HBsAg) was also determined. p,p'-DDT and/or p,p'-DDE serum levels were significantly associated with sex, area of residence, occupation, alcohol consumption and cigarette smoking. Adjusting for age, sex, area of residence, HBsAg, family history of HCC, history of acute hepatitis, smoking, alcohol, occupation (farmer vs. other) and levels of p,p'-DDT or p,p'-DDE, odds ratios (OR) and 95% confidence intervals (CI) were calculated via unconditional logistic regression. Overall, the highest quintile of p,p'-DDT was associated with an increased risk of HCC, OR = 2.96 95% CI; 1.19-7.40. There were no statistically significant associations with p,p'-DDE. Overall, these results suggest that recent exposure to p,p'-DDT may increase risk of HCC.
滴滴涕（p,p'-DDT），一种有机氯农药，已知对人类健康有有害影响，已与啮齿动物的肝细胞癌（HCC）有关。最近的一项研究报告称，滴滴涕及其最持久的代谢物，滴滴涕（p,p'-DDE），也可能与人类 HCC 有关。为了研究在 HCC 高危人群中 p,p'-DDT 和/或 p,p'-DDE 是否存在关联，在中国海门城市队列中进行了一项嵌套病例对照研究。1992 年至 1993 年期间，从所有参与者中收集了血清和问卷调查数据。本研究包括 473 名 HCC 患者和 492 名未发生 HCC 的患者，按性别、年龄和居住地区进行频数匹配。通过质谱法测定 p,p'-DDT 和 p,p'-DDE 水平。还确定了乙型肝炎病毒感染状况（基于乙型肝炎病毒表面抗原；HBsAg）。p,p'-DDT 和/或 p,p'-DDE 血清水平与性别、居住地区、职业、饮酒和吸烟显著相关。通过非条件逻辑回归调整年龄、性别、居住地区、HBsAg、HCC 家族史、急性肝炎史、吸烟、饮酒、职业（农民与其他）以及 p,p'-DDT 或 p,p'-DDE 水平后，计算比值比（OR）和 95%置信区间（CI）。总体而言，p,p'-DDT 最高五分位组 HCC 发病风险增加，OR=2.96，95%CI；1.19-7.40。与 p,p'-DDE 无统计学显著关联。总体而言，这些结果表明，最近接触 p,p'-DDT 可能会增加 HCC 的风险。
