Rotthauwe H W, Rittner C, Waiyawuth V, Becker M
Dtsch Med Wochenschr. 1976 May 28;101(22):849-54. doi: 10.1055/s-0028-1104182.
HL-A antigens were determined in 41 unrelated coeliac children and in clinically healthy parents and siblings of 40 of these patients using a lymphocyte microcytotoxicity test. 58.5% of the coeliac patients had phenotype HL-A 8 compared with an HL-A 8 frequency of 16.6% in a control group of 320 unrelated individuals (P less than 0.0005). Excluding five patients not of pure German origin HL-A 8 frequency increases to 63.9%. The increase of HL-A 1 frequency in coeliac patients is attributed to linkage disequilibrium between HL-A 8 and HL-A 1. The haplotype HL-A 1.8 frequency was significantly increased in coeliac children (P less than 0.0001) with frequency elevation also in parents (P approximately 0.025) but not in siblings. Furthermore, an increase in frequency of HL-A 12 and a decreased frequency of HL-A 7 and HL-A 9 was found in coeliac patients. Five clinically healthy siblings had the same HL-A haplotypes as their affected sisters and brothers.
采用淋巴细胞微量细胞毒性试验，对41名无亲缘关系的乳糜泻患儿以及其中40名患儿的临床健康父母和兄弟姐妹进行了HL-A抗原检测。58.5%的乳糜泻患者具有HL-A 8表型，而在320名无亲缘关系个体的对照组中，HL-A 8频率为16.6%（P小于0.0005）。排除5名非纯正德国血统的患者后，HL-A 8频率增至63.9%。乳糜泻患者中HL-A 1频率的增加归因于HL-A 8与HL-A 1之间的连锁不平衡。在乳糜泻患儿中，单倍型HL-A 1.8频率显著增加（P小于0.0001），父母中该频率也升高（P约为0.025），但兄弟姐妹中未升高。此外，还发现乳糜泻患者中HL-A 12频率增加，HL-A 7和HL-A 9频率降低。5名临床健康的兄弟姐妹与他们患病的姐妹和兄弟具有相同的HL-A单倍型。
