Shibata M, Shima M, Misu H, Okimoto Y, Giddings J C, Yoshioka A
Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan.
Haemophilia. 2003 May;9(3):269-71. doi: 10.1046/j.1365-2516.2003.00772.x.
Allergic reactions to concentrates containing factor IX (FIX) are serious complications in the treatment of haemophilia B patients with inhibitor. We have established a therapeutic protocol for such cases using an initial skin test followed by step-wise infusions of FIX concentrates under hydrocortisone cover. We have successfully treated three patients whose treatment with FIX had been suspended.