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调强放疗与三维适形放疗用于鼻窦癌的治疗计划比较

Comparison of treatment plans using intensity-modulated radiotherapy and three-dimensional conformal radiotherapy for paranasal sinus carcinoma.

作者信息

Huang David, Xia Ping, Akazawa Pam, Akazawa Clayton, Quivey Jeanne M, Verhey Lynn J, Kaplan Michael, Lee Nancy

机构信息

Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.

出版信息

Int J Radiat Oncol Biol Phys. 2003 May 1;56(1):158-68. doi: 10.1016/s0360-3016(03)00080-4.


DOI:10.1016/s0360-3016(03)00080-4
PMID:12694834
Abstract

PURPOSE: To compare intensity-modulated radiotherapy (IMRT) treatment planning with three-dimensional conformal radiotherapy (3D-CRT) planning for paranasal sinus carcinoma. MATERIALS AND METHODS: Treatment plans using traditional 3-field technique, 3D-CRT planning, and inverse planning IMRT were developed for a case of paranasal sinus cancer requiring adjuvant radiotherapy. Plans were compared with respect to dose conformality, dose-volume histograms, doses to critical normal tissues, and ease of treatment delivery. RESULTS: The inverse-planned IMRT technique was more conformal around the tumor target volume than conventional techniques. The dose-volume histograms demonstrated significantly better critical normal-tissue sparing with the IMRT plans, while able to deliver a minimum dose of 60 Gy to the clinical tumor volume and 70 Gy to the gross tumor volume. Acute toxicities in our analysis were minimal. CONCLUSIONS: IMRT planning provided improved tumor target coverage when compared to 3D-CRT treatment planning. There was significant sparing of optic structures and other normal tissues, including the brainstem. Inverse planning IMRT provided the best treatment for all paranasal sinus carcinomas, but required stringent immobilization criteria. Further studies are needed to establish the true clinical advantage of this modality.

摘要

目的:比较调强放射治疗(IMRT)与三维适形放射治疗(3D-CRT)用于鼻窦癌的治疗计划。 材料与方法:针对1例需要辅助放疗的鼻窦癌患者,制定了使用传统3野技术、3D-CRT计划和逆向计划IMRT的治疗计划。从剂量适形性、剂量体积直方图、关键正常组织的剂量以及治疗实施的难易程度等方面对计划进行了比较。 结果:与传统技术相比,逆向计划IMRT技术在肿瘤靶区周围的适形性更好。剂量体积直方图显示,IMRT计划对关键正常组织的保护明显更好;同时能够向临床肿瘤体积给予至少60 Gy的剂量,向大体肿瘤体积给予70 Gy 的剂量。我们分析中的急性毒性极小。 结论:与3D-CRT治疗计划相比,IMRT计划能更好地覆盖肿瘤靶区。对视神经结构及包括脑干在内的其他正常组织有显著的保护作用。逆向计划IMRT为所有鼻窦癌提供了最佳治疗,但需要严格的固定标准。需要进一步研究以确定这种治疗方式的真正临床优势。

相似文献

[1]
Comparison of treatment plans using intensity-modulated radiotherapy and three-dimensional conformal radiotherapy for paranasal sinus carcinoma.

Int J Radiat Oncol Biol Phys. 2003-5-1

[2]
Three-dimensional conformal radiotherapy for paranasal sinus carcinoma: clinical results for 25 patients.

Int J Radiat Oncol Biol Phys. 2003-5-1

[3]
Intensity-modulated radiotherapy in nasopharyngeal carcinoma: dosimetric advantage over conventional plans and feasibility of dose escalation.

Int J Radiat Oncol Biol Phys. 2003-5-1

[4]
Importance of protocol target definition on the ability to spare normal tissue: an IMRT and 3D-CRT planning comparison for intraorbital tumors.

Int J Radiat Oncol Biol Phys. 2005-8-1

[5]
Conformal radiation therapy treatment planning reduces the dose to the optic structures for patients with tumors of the paranasal sinuses.

Radiother Oncol. 1999-6

[6]
Intensity-modulated radiation therapy (IMRT) for locally advanced paranasal sinus tumors: incorporating clinical decisions in the optimization process.

Int J Radiat Oncol Biol Phys. 2003-3-1

[7]
Intensity-modulated radiotherapy for soft tissue sarcoma of the thigh.

Int J Radiat Oncol Biol Phys. 2004-7-1

[8]
Three-dimensional intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: the University of California-San Francisco experience.

Int J Radiat Oncol Biol Phys. 2000-10-1

[9]
Three-dimensional dosimetric evaluation of a conventional radiotherapy technique for treatment of nasopharyngeal carcinoma.

Radiother Oncol. 2001-2

[10]
Treatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: how do protons compare with other conformal techniques?

Int J Radiat Oncol Biol Phys. 2005-10-1

引用本文的文献

[1]
Locally advanced maxillary sinus cancer fed from the internal carotid artery.

Eur Arch Otorhinolaryngol. 2025-3-28

[2]
Sinonasal malignancy: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up.

ESMO Open. 2025-2

[3]
Precision Postoperative Radiotherapy in Sinonasal Carcinomas after Endonasal Endoscopic Surgery.

Cancers (Basel). 2021-9-25

[4]
Comparison of a Hybrid IMRT/VMAT technique with non-coplanar VMAT and non-coplanar IMRT for unresectable olfactory neuroblastoma using the RayStation treatment planning system-EUD, NTCP and planning study.

J Radiat Res. 2021-5-12

[5]
Comparative Study of Auto Plan and Manual Plan for Nasopharyngeal Carcinoma Intensity-Modulated Radiation Therapy.

Cancer Manag Res. 2020-12-2

[6]
Management of squamous cell carcinomas of the skull-base.

J Neurooncol. 2020-12

[7]
Multimodal Therapy for Sinonasal Malignancies: Updates and Review of Current Treatment.

Curr Treat Options Oncol. 2020-1-16

[8]
Coplanar VMAT vs. noncoplanar VMAT in the treatment of sinonasal cancer.

Strahlenther Onkol. 2015-1

[9]
A dosimetric comparison of volumetric modulated arc therapy (VMAT) and non-coplanar intensity modulated radiotherapy (IMRT) for nasal cavity and paranasal sinus cancer.

Radiat Oncol. 2014-8-30

[10]
Intensity modulated radiotherapy for sinonasal malignancies with a focus on optic pathway preservation.

J Hematol Oncol. 2013-1-7

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