Xin Xin, Cheng Chuandong, Li Churong, Li Jie, Wang Pei, Yin Gang, Lang Jinyi
Department of Radiation Therapy, Sichuan Cancer Hospital, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, People's Republic of China.
Cancer Manag Res. 2020 Dec 2;12:12439-12445. doi: 10.2147/CMAR.S226495. eCollection 2020.
Auto planning might reduce the manual time required for the optimization and could also potentially improve the overall plan quality. The aim of this study is to demonstrate the statistical comparison of automatic (AU) and manually (MA) generated nasopharyngeal carcinoma (NPC) intensity-modulated radiation therapy (IMRT) plans.
The study included 105 nasopharyngeal carcinoma patients, admitted to our hospital. The patients underwent IMRT treatments. The clinically delivered plans were performed with Eclipse (Version 11.0) using manual optimization. The same plans were optimized successively in Pinnacle (version 9.10) treatment planning system using the auto plan software package module. D95 (dose of 95% volume) and D98 (dose of 98% volume) were calculated for the targets and maximum dose (Dmax) and mean dose (Dmean) for the organ at risks (OARs); moreover, the average doses of each target and OARs for 105 patients were evaluated.
There is no significant difference in the homogeneity of the target between AU and MA treatment plans, while a significant difference is observed for what is concerning the OARs or most of OARs in 105 patients, OAR doses were significantly reduced in AU plan. For OARs which have no significant difference between AU and MA plans are highlighted, the mean dose of OARs in AU plans was at least not higher than MA plans.
Nasopharyngeal carcinoma IMRT plans made by an automatic planning tool met the clinical requirements for target prescription dose; moreover, the dose of normal tissues was lower than in MA plans. Clinical physicists' time can be saved and the influence of factors such as the lack of experience in treatment planning can be avoided.
自动计划可能会减少优化所需的人工时间，并且还可能潜在地提高总体计划质量。本研究的目的是展示自动（AU）生成和手动（MA）生成的鼻咽癌（NPC）调强放射治疗（IMRT）计划的统计学比较。
该研究纳入了我院收治的105例鼻咽癌患者。这些患者接受了IMRT治疗。临床实施的计划使用Eclipse（版本11.0）通过手动优化完成。相同的计划在Pinnacle（版本9.10）治疗计划系统中使用自动计划软件包模块依次进行优化。计算靶区的D95（95%体积的剂量）和D98（98%体积的剂量）以及危及器官（OARs）的最大剂量（Dmax）和平均剂量（Dmean）；此外，评估了105例患者每个靶区和OARs的平均剂量。
AU和MA治疗计划之间靶区的均匀性无显著差异，而在105例患者中，对于OARs或大多数OARs观察到显著差异，AU计划中OARs剂量显著降低。对于AU和MA计划之间无显著差异的OARs进行了突出显示，AU计划中OARs的平均剂量至少不高于MA计划。
由自动计划工具生成的鼻咽癌IMRT计划满足靶区处方剂量的临床要求；此外，正常组织的剂量低于MA计划。可以节省临床物理师的时间，并且可以避免诸如治疗计划经验不足等因素的影响。
