Annegers J F, Elveback L R, Labarthe D R, Hauser W A
Epilepsia. 1976 Mar;17(1):11-4. doi: 10.1111/j.1528-1157.1976.tb03376.x.
It has been suggested that patients with epilepsy and particularly those on long-term anticonvulsant medication may have a lower than expected risk of ischemic heart disease. The records of a cohort of patients with epilepsy in Rochester, Minnesota were reviewed to ascertain their rates of occurrence of ischemic heart disease. The results did not show any relative decrease in the incidence or mortality rates due to ischemic heart disease among men or women with epilepsy. The numbers of ischemic heart disease incidence and mortality cases were 25 and 15, respectively, relative to corresponding expected values of 15.0 and 15.7 new and fatal events. The use of anticonvulsant medications did not appear to influence the rates of ischemic heart disease among the patients with epilepsy. Subgroups of the epilepsy patients, by etiology and types of epilepsy, were not found to account for a disproportionate share of the ischemic heart disease. The survivorship of epilepsy patients after the initial manifestations of ischemic heart disease was comparable to that expected among all ischemic heart disease patients.
有人提出，癫痫患者，尤其是那些长期服用抗惊厥药物的患者，患缺血性心脏病的风险可能低于预期。对明尼苏达州罗切斯特市一组癫痫患者的记录进行了审查，以确定他们患缺血性心脏病的发生率。结果并未显示癫痫男性或女性因缺血性心脏病导致的发病率或死亡率有任何相对下降。缺血性心脏病的发病和死亡病例数分别为25例和15例，而相应的预期新发和致命事件数分别为15.0例和15.7例。抗惊厥药物的使用似乎并未影响癫痫患者缺血性心脏病的发病率。按病因和癫痫类型划分的癫痫患者亚组，并未发现其缺血性心脏病的比例过高。癫痫患者在缺血性心脏病初次表现后的生存率与所有缺血性心脏病患者的预期生存率相当。
