Annegers J F, Hauser W A, Shirts S B
Epilepsia. 1984 Dec;25(6):699-704. doi: 10.1111/j.1528-1157.1984.tb03480.x.
All-cause and heart disease mortality and ischemic heart disease incidence among patients with an initial diagnosis of epilepsy while residents of Rochester, MN, from 1935 through 1979 were determined. Death rates from heart disease were slightly elevated for persons with epilepsy. The increased death rate from heart disease was confined to persons less than 65 years of age. The incidence of ischemic heart disease and of sudden cardiac death as the initial manifestation of ischemic heart disease was significantly increased in persons with epilepsy, but the increase was primarily limited to those with symptomatic epilepsy attributed to cerebrovascular disease. The occurrence of ischemic heart disease and sudden cardiac death was not related to anticonvulsant medication status.
确定了1935年至1979年期间，明尼苏达州罗切斯特市首次诊断为癫痫的患者的全因死亡率、心脏病死亡率以及缺血性心脏病发病率。癫痫患者的心脏病死亡率略有升高。心脏病死亡率的增加仅限于65岁以下的人群。癫痫患者中，缺血性心脏病的发病率以及以缺血性心脏病为首发表现的心脏性猝死的发病率显著增加，但这种增加主要限于患有因脑血管疾病导致的症状性癫痫的患者。缺血性心脏病和心脏性猝死的发生与抗惊厥药物使用状况无关。
