Belli Paolo, Pastore Giovanna, Romani Maurizio, Terribile Daniela, Canadè Adolfo, Costantini Melania
Istituto di Radiologia, Università Cattolica del S. Cuore, Policlinico A. Gemelli, Largo A. Gemelli 8, 00168 Roma, Italy.
Rays. 2002 Oct-Dec;27(4):241-57.
The sensitivity, specificity and accuracy of MRI in detecting breast cancer recurrence were analyzed. 40 patients undergoing breast conserving therapy were studied with MRI. Cytohistologic examinations of suspected local recurrence were carried out. In these patients, the clinical, mammographic and sonographic characteristics of local recurrence were nonspecific or dubious. All patients were examined at least 1 year after completion of radiation therapy. Qualitative and quantitative information was acquired with dynamic MRI. Statistical analysis was performed with the Student's t test. Breast cancer recurrence identified in 22 patients was confirmed on histology in all of them. There were only 2 cases of false positive results. MRI showed 95% accuracy, 100% sensitivity and 88.8% specificity with 5% false-positives and 100% negative predictive value. Dynamic MRI appears a valuable technique for differentiation of post-treatment changes in recurrent carcinoma and for guiding the histological confirmation.
分析了MRI检测乳腺癌复发的敏感性、特异性和准确性。对40例接受保乳治疗的患者进行了MRI研究。对疑似局部复发进行了细胞组织学检查。在这些患者中，局部复发的临床、乳腺X线和超声特征不具有特异性或存在疑问。所有患者在放疗结束后至少1年接受检查。通过动态MRI获取定性和定量信息。采用Student's t检验进行统计分析。22例患者中经MRI确定的乳腺癌复发均经组织学证实。仅有2例假阳性结果。MRI的准确率为95%，敏感性为100%，特异性为88.8%，假阳性率为5%，阴性预测值为100%。动态MRI似乎是一种用于鉴别复发性癌治疗后变化以及指导组织学确诊的有价值技术。
