Leal Patrícia F, Braga Mara E M, Sato Daisy N, Carvalho João E, Marques Marcia O M, Meireles M Angela A
LASEFI-DEA/FEA-UNICAMP (State University of Campinas), Caixa Postal 6121, 13083-970 Campinas, São Paulo, Brazil.
J Agric Food Chem. 2003 Apr 23;51(9):2520-5. doi: 10.1021/jf0260693.
In the present study the antioxidant, anticancer, and antimycobacterial activities of extracts from ginger (Zingiber officinale Roscoe), rosemary (Rosmarinus officinalis L.), and turmeric (Curcuma longa L.) were evaluated. The extracts were obtained using supercritical CO(2) with and without ethanol and/or isopropyl alcohol as cosolvent. The extracts' antioxidant power was assessed using the reaction between beta-carotene and linolenic acid, the antimycobacterial activity against M. tuberculosis was measured by the MABA test, and their anticancer action was tested against nine human cancer ancestries: lung, breast, breast resistant, melanoma, colon, prostate, leukemia, and kidney. The rosemary extracts exhibited the strongest antioxidant and the lowest antimycobacterial activities. Turmeric extracts showed the greatest antimycobacterial activity. Ginger and turmeric extracts showed selective anticancer activities.
在本研究中,对生姜(姜科姜属植物姜Zingiber officinale Roscoe)、迷迭香(唇形科迷迭香属植物迷迭香Rosmarinus officinalis L.)和姜黄(姜科姜黄属植物姜黄Curcuma longa L.)提取物的抗氧化、抗癌和抗分枝杆菌活性进行了评估。提取物采用超临界CO₂ 制备,添加或不添加乙醇和/或异丙醇作为共溶剂。使用β-胡萝卜素与亚麻酸之间的反应评估提取物的抗氧化能力,通过MABA试验测定其对结核分枝杆菌的抗分枝杆菌活性,并针对九种人类癌症谱系测试其抗癌作用:肺癌、乳腺癌、耐乳腺癌、黑色素瘤、结肠癌、前列腺癌、白血病和肾癌。迷迭香提取物表现出最强的抗氧化活性和最低的抗分枝杆菌活性。姜黄提取物表现出最大的抗分枝杆菌活性。生姜和姜黄提取物表现出选择性抗癌活性。