Ma Fu-bao, Zheng Li, Bi Cheng, Tao Hong, Zhou Yong-lin, Zhang Jin-lin, Tang Fen-yang, Xie Ping, Zheng Chun-zao, Peng Wei-bin, Jiang Ren-jie
Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Feb;24(2):113-5.
Using the advantages of Japanese encephalitis live attenuated and inactivated vaccine, to reduce the rate of immunization reaction and to increase the effect, we conducted a study on the strategy of immunization in Japanese encephalitis using live attenuated vaccine combined with inactivated vaccine.
Observing the safety and immune effects of different groups.
Data on side effect showed that the rate of moderate and severe systematic reactions of the group who were inoculated with combined vaccine was 0.73%, with local reaction 1.46% while the combined rate of moderate and severe systematic reaction of the group who were inoculated with inactivated vaccine was 2.8%. Under the detection of serum neutralizing antibody, the GMT rose from 1:1.05 - 1:3.35 before vaccination to 1:47.34 - 1:101.30 after vaccination in the different groups. Neutralizing antibody was detected in 97.67% of the combined group. There was a significant difference by comparing neutralizing antibody seroconversion rate of the combined group with the inactivated group (chi(2) = 3.89, P < 0.05), but no significant difference with attenuated group (chi(2) = 0.74, P > 0.05).
Results showed that in children who previously had been immunized with two doses of inactivated vaccine, the booster administration of live attenuated vaccine was both effective and safe.
利用乙型脑炎减毒活疫苗和灭活疫苗的优势，降低免疫反应发生率并提高免疫效果，我们开展了一项关于使用减毒活疫苗与灭活疫苗联合进行乙型脑炎免疫策略的研究。
观察不同组别的安全性和免疫效果。
副作用数据显示，接种联合疫苗组的中重度全身反应发生率为0.73%，局部反应发生率为1.46%，而接种灭活疫苗组的中重度全身反应合并发生率为2.8%。在血清中和抗体检测下，不同组别的几何平均滴度（GMT）从接种前的1:1.05 - 1:3.35升至接种后的1:47.34 - 1:101.30。联合组97.67%检测到中和抗体。联合组与灭活组比较中和抗体血清转化率有显著差异（χ² = 3.89，P < 0.05），但与减毒组比较无显著差异（χ² = 0.74，P > 0.05）。
结果表明，对于先前已接种两剂灭活疫苗的儿童，加强接种减毒活疫苗既有效又安全。
