Ceriani D, Di Giulio A M, Panelli M
Farmaco Sci. 1976 May;31(5):379-87.
The absorption, excretion and metabolism of a new diuretic compound, 2-phenyl-6-sulfonamido-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone (M.G. 13054), after oral administration to the dog have been studied. The results can be summarized as follows: 1) M.G. 13054 given orally to dogs is quickly absorbed. 2) The maximal blood levels are reached within the 3rd hour after the administration and remain appreciable (10% of the maximal values) till the 12th hour. 3) Fecal and urinary excretion is rapid and 94% of the product administered is excreted in the first 48 hours following treatment. 4) The product does not seem to be tightly bound to plasma proteins. 5) M. G. 13054 does not seem to be metabolized to any appreciable extent.
对一种新型利尿化合物2-苯基-6-磺酰胺基-7-氯-1,2,3,4-四氢-4-喹唑啉酮（M.G. 13054）进行了犬口服给药后的吸收、排泄及代谢研究。结果可总结如下：1）犬口服M.G. 13054后吸收迅速。2）给药后3小时内达到最高血药浓度，直至12小时仍保持可观水平（最高值的10%）。3）粪便和尿液排泄迅速，给药后48小时内94%的给药产物排出体外。4）该产物似乎与血浆蛋白结合不紧密。5）M.G. 13054似乎未发生明显代谢。
