Placidi G F, Fornaro P, Guarneri M
Arzneimittelforschung. 1979;29(7):1005-8.
The distribution of 2-phenyl-6-sulfonamido-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone (fenquizone, M.G. 13054) labelled with 14C in mice was studied by means of an autoradiographic technique. High concentration of radioactivity was found in the intestine, liver, kidney, blood, myocardium and skeletal muscles in decreasing order at various times after oral administration. The drug was easily absorbed in the intestine reaching the highest concentration between 2 and 4 hr. The labelled compound did not cross the blood-brain barrier.
采用放射自显影技术研究了在小鼠体内用¹⁴C标记的2-苯基-6-磺酰胺基-7-氯-1,2,3,4-四氢-4-喹唑啉酮（芬喹酮，M.G. 13054）的分布情况。口服给药后不同时间，在肠道、肝脏、肾脏、血液、心肌和骨骼肌中发现放射性浓度较高，且浓度从高到低依次排列。该药物在肠道易于吸收，在2至4小时之间达到最高浓度。标记化合物未穿过血脑屏障。
