Redegeld Frank A, Nijkamp Frans P
Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16/PO Box 80082, 3508TB Utrecht, The Netherlands.
Trends Immunol. 2003 Apr;24(4):181-5. doi: 10.1016/s1471-4906(03)00059-0.
Immunoglobulin (Ig) free light (L)-chains have long been considered as the meaningless remnants of a spillover in the regular Ig production by B cells. The recently discovered role for Ig free L-chains in mediating hypersensitivity-like responses sheds new light on their potential role in immune responses. Ig free L-chains can sensitize mast cells, such that a second encounter with the appropriate antigen results in mast-cell activation. The possible importance of this reaction for the induction of T-cell-mediated immune reactions, leading to contact sensitivity, multiple sclerosis and rheumatoid arthritis is discussed.
免疫球蛋白（Ig）游离轻（L）链长期以来一直被视为B细胞正常Ig产生过程中溢出的无意义残余物。最近发现的Ig游离L链在介导超敏样反应中的作用为其在免疫反应中的潜在作用提供了新的线索。Ig游离L链可使肥大细胞致敏，因此再次接触适当抗原会导致肥大细胞活化。本文讨论了这种反应在诱导T细胞介导的免疫反应中可能的重要性，这种免疫反应会导致接触性过敏、多发性硬化症和类风湿性关节炎。
