Sun Chien-An, Wu Der-Min, Lin Chia-Chin, Lu Sheng-Nan, You San-Lin, Wang Li-Yu, Wu Mei-Hsuan, Chen Chien-Jen
School of Public Health, National Defense Medical Center, Taipei, Taiwan.
Am J Epidemiol. 2003 Apr 15;157(8):674-82. doi: 10.1093/aje/kwg041.
In a community-based prospective study, the authors examined the independent and interactive effects of hepatitis C virus (HCV) infection and cofactors, including hepatitis B virus (HBV) infection and lifestyle habits, on the incidence of hepatocellular carcinoma (HCC) in Taiwan. At baseline recruitment, subjects were evaluated with regard to second-generation HCV antibody (anti-HCV), hepatitis B surface antigen, and serum alanine aminotransferase, as well as cigarette smoking, alcohol drinking, and betel quid chewing habits. A total of 12,008 male residents aged 30-64 years without a history of HCC were included in the study. Between July 1990 and June 2001, 112 incident cases of HCC were identified among the subjects and included in the analysis. Persons with anti-HCV positivity alone had a 20-fold increased risk of developing HCC in comparison with those who were negative for anti-HCV. In statistical assessment of additive interaction, HCV and HBV tended to act independently in the pathogenesis of HCC. The results of this study suggest that HCV plays a significant role in hepatocarcinogenesis in an area endemic for chronic HBV infection.
在一项基于社区的前瞻性研究中，作者研究了丙型肝炎病毒（HCV）感染及包括乙型肝炎病毒（HBV）感染和生活习惯等辅助因素对台湾肝细胞癌（HCC）发病率的独立及交互作用。在基线招募时，对受试者进行了第二代HCV抗体（抗-HCV）、乙型肝炎表面抗原、血清丙氨酸转氨酶评估，以及吸烟、饮酒和嚼槟榔习惯评估。共有12008名年龄在30至64岁之间且无HCC病史的男性居民纳入该研究。在1990年7月至2001年6月期间，在这些受试者中确定了112例HCC发病病例并纳入分析。单纯抗-HCV阳性者发生HCC的风险比抗-HCV阴性者高20倍。在对相加交互作用的统计学评估中，HCV和HBV在HCC发病机制中倾向于独立起作用。本研究结果表明，在慢性HBV感染流行地区，HCV在肝癌发生中起重要作用。
