Lopez-Saez Juan-Bosco, Senra-Varela Avelino, Pousa-Estevez Lorenzo
Department of Medicine, University of Cadiz School of Medicine, c/Dr. Marañón 6, E-11002 Cadiz, Spain.
Oncology. 2003;64(3):227-31. doi: 10.1159/000069312.
Controversy surrounds the hypothetical relationship between low serum levels of selenium and reduced activity of selenium-dependent enzymes, such as glutathione peroxidase, and an increased risk of cancer in humans. This study investigated serum concentrations of selenium in women with and without breast cancer.
In this case-control study, we compared serum concentrations of selenium in women with breast cancer (n = 200), healthy women (n = 100), and women with chronic diseases (n = 100). Patients with breast cancer were divided into premenopausal (n = 99) and postmenopausal subjects (n = 101).
Mean serum concentrations of selenium were 81.1 microg/l in women with breast cancer and 98.5 microg/l in women with non-tumoral disease (p < 0.001).
Alterations in serum concentrations of selenium in women with breast cancer appear to be a consequence, rather than a cause of cancer. In accordance with the hypothesis, the findings suggest that very low selenium status could be due to the nature of cancer.
血清硒水平低与硒依赖酶（如谷胱甘肽过氧化物酶）活性降低以及人类患癌风险增加之间的假设关系存在争议。本研究调查了患乳腺癌和未患乳腺癌女性的血清硒浓度。
在这项病例对照研究中，我们比较了乳腺癌女性（n = 200）、健康女性（n = 100）和患有慢性疾病女性（n = 100）的血清硒浓度。乳腺癌患者分为绝经前（n = 99）和绝经后受试者（n = 101）。
乳腺癌女性的平均血清硒浓度为81.1微克/升，非肿瘤疾病女性为98.5微克/升（p < 0.001）。
乳腺癌女性血清硒浓度的改变似乎是癌症的结果，而非原因。与该假设一致，研究结果表明极低的硒状态可能归因于癌症的本质。
Zotero 插件