Männistö S, Alfthan G, Virtanen M, Kataja V, Uusitupa M, Pietinen P
National Public Health Institute, Department of Nutrition, Mannerheimintie 166, Helsinki, Finland.
Eur J Clin Nutr. 2000 Feb;54(2):98-103. doi: 10.1038/sj.ejcn.1600902.
Low levels of selenium have been associated with a higher risk of cardiovascular diseases and cancer in humans. Since 1984, selenium supplementation through fertilizers has been employed in Finland to increase the very low concentration of selenium in the nation's food supply. As a result, the selenium concentration of Finnish foods became one of the highest in Europe. A decade after selenium supplementation began, the association between toenail selenium and the risk of breast cancer was examined.
Case-control study.
Eastern Finland.
289 pre- and postmenopausal breast cancer cases and 433 community controls. The diagnosis was unknown at the time the toenail samples were collected.
The mean toenail selenium concentration was 0.80 mg/kg in premenopausal cases and 0.84 mg/kg in premenopausal controls: and 0. 77 mg/kg in postmenopausal cases and 0.80 mg/kg in postmenopausal controls. The odds ratio (OR) comparing the highest with the lowest quintiles of toenail selenium concentration was 1.1 (95% CI 0.4-3.2) in premenopausal women and 0.7 (95% CI 0.3-1.5) in postmenopausal women. The intake of retinol, beta-carotene, vitamin E and vitamin C did not change the association between toenail selenium and breast cancer.
A decade after selenium supplementation, selenium seems not to be an important factor in the etiology of breast cancer, neither in premenopausal nor postmenopausal women.
This work was supported by the EVO funds from the Kuopio University Hospital and by research grants from the Academy of Finland, Yrjö Jahnsson Foundation and Juho Vainio Foundation. European Journal of Clinical Nutrition (2000) 54, 98-103
低硒水平与人类心血管疾病和癌症的较高风险相关。自1984年以来，芬兰通过肥料补充硒，以提高该国食物供应中极低的硒浓度。结果，芬兰食物中的硒浓度成为欧洲最高的之一。在开始补充硒十年后，研究了趾甲硒与乳腺癌风险之间的关联。
病例对照研究。
芬兰东部。
289例绝经前和绝经后乳腺癌病例以及433例社区对照。在采集趾甲样本时，诊断情况未知。
绝经前病例的趾甲硒平均浓度为0.80毫克/千克，绝经前对照为0.84毫克/千克；绝经后病例为0.77毫克/千克，绝经后对照为0.80毫克/千克。将趾甲硒浓度最高与最低五分位数进行比较，绝经前女性的优势比（OR）为1.1（95%可信区间0.4 - 3.2），绝经后女性为0.7（95%可信区间0.3 - 1.5）。视黄醇、β-胡萝卜素、维生素E和维生素C的摄入量并未改变趾甲硒与乳腺癌之间的关联。
补充硒十年后，硒似乎不是乳腺癌病因中的重要因素，无论是在绝经前还是绝经后女性中。
这项工作得到了库奥皮奥大学医院的EVO基金以及芬兰科学院、伊尔约·亚恩松基金会和尤霍·瓦伊尼奥基金会的研究资助。《欧洲临床营养学杂志》（2000年）54卷，98 - 103页
