Sung L, Greenberg M L, Doyle J J, Young N L, Ingber S, Rubenstein J, Wong J, Samanta T, McLimont M, Feldman B M
Department of Health Policy Management and Evaluation, University of Toronto, Ontario, Canada.
Br J Cancer. 2003 Apr 22;88(8):1185-90. doi: 10.1038/sj.bjc.6600895.
The objective of this study was to evaluate the construct validity of two questionnaire-based measures of health-related quality of life (HRQL) in children undergoing cancer chemotherapy: the Health Utilities Index (HUI) and the Child Health Questionnaire (CHQ). Subjects were children hospitalised for chemotherapy. To examine construct validity: (1). a priori expected relations between CHQ concepts and HUI attributes were examined; (2). HUI and CHQ summary scores were compared to visual analogue scale (VAS) scores. Ease of completion was rated using a 5-point categorical scale and completion time was recorded. A total of 36 subjects were included. The maximum score was seen in 15 (47%) of HUI3 assessments. As predicted, CHQ body pain was moderately correlated with HUI3 pain (r=0.51), CHQ physical functioning was moderately correlated with HUI2 mobility (r=0.58) and CHQ mental health was moderately correlated with HUI2 emotion (r=0.53). Only the CHQ psychosocial subscale (and not HUI) was correlated with VAS (r=0.44). The CHQ and the HUI were both easy to use. The HUI questionnaires required less time to complete (mean=3.1, s.d.=1 min) compared with CHQ (mean=13.1, s.d.=3.4 min, P<0.0001). In conclusion, HUI and CHQ demonstrated construct validity in children undergoing cancer chemotherapy. The Health Utilities Index is subject to a ceiling effect whereas CHQ requires more time to complete.
本研究的目的是评估两种基于问卷的健康相关生活质量（HRQL）测量方法在接受癌症化疗儿童中的结构效度：健康效用指数（HUI）和儿童健康问卷（CHQ）。研究对象为因化疗住院的儿童。为检验结构效度：（1）检查CHQ概念与HUI属性之间的先验预期关系；（2）将HUI和CHQ的汇总得分与视觉模拟量表（VAS）得分进行比较。使用5分分类量表对完成的难易程度进行评分，并记录完成时间。共纳入36名受试者。在15项（47%）HUI3评估中出现了最高分。正如预期的那样，CHQ身体疼痛与HUI3疼痛中度相关（r=0.51），CHQ身体功能与HUI2活动能力中度相关（r=0.58），CHQ心理健康与HUI2情绪中度相关（r=0.53）。只有CHQ心理社会子量表（而非HUI）与VAS相关（r=0.44）。CHQ和HUI都易于使用。与CHQ（平均=13.1，标准差=3.4分钟，P<0.0001）相比，HUI问卷完成所需时间更少（平均=3.1，标准差=1分钟）。总之，HUI和CHQ在接受癌症化疗的儿童中显示出结构效度。健康效用指数存在天花板效应，而CHQ完成需要更多时间。
