Nixon Speechley K, Maunsell E, Desmeules M, Schanzer D, Landgraf J M, Feeny D H, Barrera M E
Departments of Pediatrics and of Epidemiology and Biostatistics, University of Western Ontario and the Child Health Research Institute, London, Canada.
Int J Cancer Suppl. 1999;12:95-105. doi: 10.1002/(sici)1097-0215(1999)83:12+<95::aid-ijc18>3.0.co;2-h.
Mutual concurrent validity of 2 generic measures of health-related quality of life (HRQL), the Child Health Questionnaire (CHQ) and the Health Utilities Index Mark 2 (HUI2) and HUI3, was assessed. Data were from 3 centers participating in a Canadian multi-center retrospective cohort study currently in progress to assess psycho-social and physical late effects in children surviving >/=5 years after cancer diagnosis between 1981 and 1990. Exploratory results are from 244 parent reports on HRQL in children <16 years old when studied. Spearman rank-order correlations between sub-scale scores for the CHQ and single-attribute utility scores for the corresponding attribute from the HUI2 and HUI3 were used. As predicted, the correlation between CHQ bodily pain and HUI2 and HUI3 pain was strong, 0.58 and 0.60, respectively, while correlations between CHQ physical functioning and HUI2 mobility and HUI3 ambulation were moderate, both 0.45. Correlations between CHQ mental health and HUI2 and HUI3 emotion were strong, 0.64 and 0.54, respectively, rather than moderate, as predicted. Both the CHQ general health scale and the general health single item were moderately correlated with the HUI2 and HUI3 global utility scores rather than weakly, as predicted (CHQ general health scale and HUI2 and HUI3 global utility were 0.43 and 0.44, respectively; CHQ general health single item and HUI2 and HUI3 global utility were 0. 38 and 0.42, respectively). The CHQ and HUI, which are based on different methodologies (summative Likert scaling and utility analysis, respectively), appear to capture similar constructs in childhood cancer survivors.
对两种通用的健康相关生活质量（HRQL）测量方法——儿童健康问卷（CHQ）以及健康效用指数Mark 2（HUI2）和HUI3——的相互同时效度进行了评估。数据来自参与一项加拿大多中心回顾性队列研究的3个中心，该研究目前正在进行，旨在评估1981年至1990年间癌症诊断后存活≥5年的儿童的心理社会和身体远期效应。探索性结果来自于对244名16岁以下儿童的家长关于HRQL的报告。使用了CHQ子量表得分与HUI2和HUI3相应属性的单属性效用得分之间的斯皮尔曼等级相关。正如所预测的，CHQ身体疼痛与HUI2和HUI3疼痛之间的相关性很强，分别为0.58和0.60，而CHQ身体功能与HUI2活动能力和HUI3行走能力之间的相关性为中等，均为0.45。CHQ心理健康与HUI2和HUI3情绪之间的相关性很强，分别为0.64和0.54，而不是如所预测的中等。CHQ总体健康量表和总体健康单项与HUI2和HUI3总体效用得分的相关性为中等，而不是如所预测的弱（CHQ总体健康量表与HUI2和HUI3总体效用分别为0.43和0.44；CHQ总体健康单项与HUI2和HUI3总体效用分别为0.38和0.42）。基于不同方法（分别为累加李克特量表法和效用分析法）的CHQ和HUI，似乎在儿童癌症幸存者中捕捉到了相似的结构。
