Aronoff S L, Bennett P H, Rushforth N B, Miller M, Unger R H
Diabetes. 1976 May;25(5):404-7. doi: 10.2337/diab.25.5.404.
Groups of 27 nondiabetic Pima Indians, 34 nondiabetic Caucasians, and 12 diabetic Pima Indians with recent onset of their disease received an arginine infusion to determine if (1) nondiabetic Pima Indians and Caucasians had a similar glucagon response to arginine and (2) diabetic Pimas had excessive glucagon response to arginine as reported in other racial groups. The fasting glucagon levels in the three groups were not significantly different. During arginine monochloride infusion (5 mg./kg./minute for 40 minutes) the diabetic Pimas had glucagon levels significantly higher at 10 minutes and at all sampling points thereafter than the normo-glycemic Pimas. Plasma insulin levels also increased during the infusion but, notably, never differed significantly between these two groups. There was no significant difference in the glucagon levels at any sampling point between the nondiabetic Pimas and Caucasians. The differences in glucagon levels between the nondiabetic and diabetic Indians are similar to those differences reported between diabetic and nondiabetic subjects of other racial origins.
27名非糖尿病皮马印第安人、34名非糖尿病高加索人以及12名近期发病的糖尿病皮马印第安人被分成几组，接受精氨酸输注，以确定：（1）非糖尿病皮马印第安人和高加索人对精氨酸的胰高血糖素反应是否相似；（2）糖尿病皮马人是否像其他种族群体中所报道的那样，对精氨酸有过度的胰高血糖素反应。三组的空腹胰高血糖素水平无显著差异。在输注一氯精氨酸期间（5毫克/千克/分钟，持续40分钟），糖尿病皮马人在10分钟时以及此后的所有采样点的胰高血糖素水平均显著高于血糖正常的皮马人。输注期间血浆胰岛素水平也有所升高，但值得注意的是，这两组之间血浆胰岛素水平从未有显著差异。非糖尿病皮马人和高加索人在任何采样点的胰高血糖素水平均无显著差异。非糖尿病和糖尿病印第安人之间胰高血糖素水平的差异与其他种族起源的糖尿病和非糖尿病受试者之间所报道的差异相似。
