Hamlyn A N, Morris J S, Sarkany I, Sherlock S
Gastroenterology. 1976 Jun;70(6):1144-7.
The first reported case of piperazine toxicity resembling viral hepatitis is described in a 25-year-old woman. The illness, which was severe, occurred after administration of the drug on two separate occasions. The evidence favors a hypersensitivity mechanism rather than a direct toxic effect of piperazine or its metabolites on the liver. The humoral or cellular immune basis for such hypersensitivity has not been elucidated.
首例类似病毒性肝炎的哌嗪中毒病例在一名25岁女性中被报道。该疾病较为严重，在两次单独服用该药物后发生。证据支持超敏反应机制，而非哌嗪及其代谢产物对肝脏的直接毒性作用。这种超敏反应的体液或细胞免疫基础尚未阐明。
