Bartoli E, Massarelli G, Solinas A, Faedda R, Chiandussi L
Arch Intern Med. 1979 Jun;139(6):698-9.
A 59-year-old woman was admitted to the hospital for evaluation of her hypertension. She was treated with hydralazine; two days later a severe acute hepatitis supervened. On discontinuation of the agent, the liver damage disappeared, relapsed during inadvertent rechallenge, and healed following permanent withdrawal from the drug. Histologic study of the liver showed severe acute hepatitis with bridging necrosis (so-called subacute hepatitis). Six months after discontinuation of hydralazine, a second liver biopsy specimen showed a complete remission of the disease. This hydralazine-induced hepatitis appears to be fully reversible and to differ both on clinical and histological grounds from two previous reports documenting a granulomatous liver disease.
一名59岁女性因高血压入院评估。她接受了肼屈嗪治疗；两天后出现了严重的急性肝炎。停用该药物后，肝损伤消失，在无意中再次用药时复发，在永久停药后痊愈。肝脏组织学研究显示为伴有桥接坏死的严重急性肝炎（所谓的亚急性肝炎）。停用肼屈嗪六个月后，第二次肝脏活检标本显示疾病完全缓解。这种由肼屈嗪引起的肝炎似乎完全可逆，在临床和组织学方面均与之前两篇记录肉芽肿性肝病的报告不同。
