Shipilova Tatjana, Pshenichnikov Igor, Kaik Jüri, Volozh Olga, Abina Jelena, Kalev Maie, Lass Jaanus, Karai Denis
Department of Clinical Cardiology of Estonian Institute of Cardiology, Tallinn, Estonia.
Blood Press. 2003;12(1):12-8.
The aim of the present study was to determine the prevalence of Left ventricular hypertrophy (LVH) and different left ventricular (LV) geometric patterns in the middle-aged women population of Tallinn, to assess the relationship between LV geometry, age, blood pressure and LV repolarization duration and inhomogeneity. A random sample of the population, 482 women aged 35-59, was examined in the framework of a cardiovascular risk factors survey for the WHO/CINDI programme years 1999-2000. Patients with valvular pathology, primary cardiomyopathy, atrial fibrillation, bundle branch blocks and flat T wave on electrocardiography (ECG) were excluded; 398 (82.2%) of the participants underwent echocardiography (Echo) and standard 12-lead ECG at rest and were included in the study. LVH was defined if left ventricular mass (LVM), LVM/height and LVM/BSA were >198 g, >121 g/m and > 120 g/m2, respectively. Arterial hypertension was determined in 23.1% of the women. The prevalence of arterial hypertension was three times higher in those aged 50-59 than in those aged 40-49 (37.4% vs 13.2%; p < 0.05). Different geometric patterns were found as follows: concentric hypertrophy in 9.1%; eccentric hypertrophy 33.9%; concentric remodelling 9.5% and normal geometry 47.5% of the participants. Concentric hypertrophy was found exclusively in hypertensive women and increased with age. No age-related eccentric hypertrophy and concentric remodelling differences were found, either in the normotensive or in the hypertensive group. Prolonged QT dispersion--a marker of increased myocardial electrical instability, was associated with LVH and arterial hypertension and was related mostly to concentric hypertrophy in hypertensives.
本研究的目的是确定塔林中年女性人群中左心室肥厚(LVH)的患病率及不同的左心室(LV)几何形态,评估LV几何形态、年龄、血压与LV复极持续时间及不均一性之间的关系。在1999 - 2000年WHO/CINDI项目心血管危险因素调查框架内,对482名年龄在35 - 59岁的女性人群进行了随机抽样检查。排除患有瓣膜病变、原发性心肌病、心房颤动、束支传导阻滞以及心电图(ECG)上T波平坦的患者;398名(82.2%)参与者接受了静息状态下的超声心动图(Echo)检查和标准12导联ECG检查,并纳入研究。若左心室质量(LVM)、LVM/身高和LVM/体表面积分别>198 g、>121 g/m和>120 g/m²,则定义为LVH。23.1%的女性被诊断为动脉高血压。50 - 59岁女性的动脉高血压患病率比40 - 49岁女性高两倍(37.4%对13.2%;p<0.05)。发现了不同的几何形态如下:向心性肥厚占9.1%;离心性肥厚占33.9%;向心性重构占9.5%;正常几何形态占47.5%。向心性肥厚仅在高血压女性中发现,且随年龄增加。在正常血压组或高血压组中,均未发现与年龄相关的离心性肥厚和向心性重构差异。QT离散度延长——心肌电不稳定性增加的一个指标,与LVH和动脉高血压相关,且在高血压患者中主要与向心性肥厚有关。