5-咪唑基喹啉酮、喹唑啉酮和苯并氮杂卓酮作为法尼基转移酶抑制剂
5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors.
作者信息
Angibaud Patrick, Bourdrez Xavier, Devine Ann, End David W, Freyne Eddy, Ligny Yannick, Muller Philippe, Mannens Geert, Pilatte Isabelle, Poncelet Virginie, Skrzat Stacy, Smets Gerda, Van Dun Jacky, Van Remoortere Pieter, Venet Marc, Wouters Walter
机构信息
Medicinal Chemistry Department, Johnson & Johnson Pharmaceutical Research & Development, Campus de Maigremont BP615, 27106 Val de Reuil, France.
出版信息
Bioorg Med Chem Lett. 2003 May 5;13(9):1543-7. doi: 10.1016/s0960-894x(03)00180-x.
Abstract
The evaluation of structure-activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described.
摘要
描述了与显示出强大体外抑制活性的R115777喹啉酮环部分修饰相关的构效关系评估。
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