细菌细胞壁生物合成酶MurD的大环抑制剂。
Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme MurD.
作者信息
Horton James R, Bostock Julieanne M, Chopra Ian, Hesse Lars, Phillips Simon E V, Adams David J, Johnson A Peter, Fishwick Colin W G
机构信息
Departments of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
出版信息
Bioorg Med Chem Lett. 2003 May 5;13(9):1557-60. doi: 10.1016/s0960-894x(03)00176-8.
Abstract
Computer-based molecular design has been used to produce a series of new macrocyclic systems targeted against the bacterial cell wall biosynthetic enzyme MurD. Following their preparation, which involved a novel metathesis-based cyclisation as the key step, these systems were found to show good inhibition when assayed against the MurD enzyme.
摘要
基于计算机的分子设计已被用于制备一系列针对细菌细胞壁生物合成酶MurD的新型大环系统。在制备过程中，以一种基于复分解的新型环化反应为关键步骤，这些系统在针对MurD酶进行检测时显示出良好的抑制作用。
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