细菌细胞壁生物合成酶MurD的抑制剂。
Inhibitors of the bacterial cell wall biosynthesis enzyme MurD.
作者信息
Gegnas L D, Waddell S T, Chabin R M, Reddy S, Wong K K
机构信息
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
出版信息
Bioorg Med Chem Lett. 1998 Jul 7;8(13):1643-8. doi: 10.1016/s0960-894x(98)00285-6.
PMID:9873406
Abstract
A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.
摘要
已合成了一系列细菌肽聚糖生物合成中D-谷氨酸添加酶（MurD）的过渡态类似物抑制剂，并对其抑制大肠杆菌该酶的能力进行了评估。
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