Antiretroviral resistance associated with supervised treatment interruptions in treated acute HIV infection.
作者信息
Tremblay Cecile L, Hicks Jennifer L, Sutton Lorraine, Giguel Francoise, Flynn Theresa, Johnston Mary, Sax Paul E, Walker Bruce D, Hirsch Martin S, Rosenberg Eric S, D'Aquila Richard T
机构信息
Massachusetts General Hospital and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
AIDS. 2003 May 2;17(7):1086-9. doi: 10.1097/00002030-200305020-00021.
We studied 14 patients acutely infected with wild-type HIV, who underwent supervised treatment interruptions after initial antiretroviral treatment including lamivudine. Lamivudine resistance mutations emerged for the first time during supervised treatment interruptions in one patient. Resistance should be monitored in supervised treatment interruptions trials, because mutations may first be detected only after therapy is interrupted.
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