Ayhan A, Guvenal T, Coskun F, Basaran M, Salman M C
Department of Obstetrics and Gynecology, Hacettepe University School of Medicine Ankara, Turkey.
Eur J Gynaecol Oncol. 2003;24(2):171-4.
To compare the survival and prognostic factors of patients with synchronous primary ovarian and endometrial cancers, and endometrial cancers metastatic to the ovaries.
Fifty-three patients with synchronous primary ovarian and endometrial cancer and 64 patients with endometrial cancer metastatic to the ovaries were evaluated.
Mean follow-up time was 47.2 months (18-170 months). There was no statistical difference in age, gravidity and parity between the two groups. Abnormal vaginal bleeding was the most common symptom in both groups. All patients were subjected to a surgical staging procedure. Overall survival of the synchronous group was significantly higher than that of the metastatic group (98 +/- 12 vs 59 +/- 6 months; p = 0.048). The significant prognostic factors for synchronous cancers after multivariate analysis were age, stage of ovarian cancer, grade of endometrial cancer, and adjuvant therapy status.
Patients with synchronous ovarian and endometrial cancers appear to have a good prognosis and should undergo primary surgical staging since the stage of tumors is a significant prognostic factor.
比较同时性原发性卵巢癌和子宫内膜癌患者以及卵巢转移的子宫内膜癌患者的生存率和预后因素。
对53例同时性原发性卵巢癌和子宫内膜癌患者以及64例卵巢转移的子宫内膜癌患者进行了评估。
平均随访时间为47.2个月（18 - 170个月）。两组患者的年龄、妊娠次数和产次无统计学差异。异常阴道出血是两组最常见的症状。所有患者均接受了手术分期程序。同时性组的总生存期显著高于转移组（98±12个月对59±6个月；p = 0.048）。多因素分析后，同时性癌症的显著预后因素为年龄、卵巢癌分期、子宫内膜癌分级和辅助治疗状态。
同时性卵巢癌和子宫内膜癌患者似乎预后良好，由于肿瘤分期是一个重要的预后因素，因此应进行初次手术分期。
