Oranratanaphan Shina, Manchana Tarinee, Sirisabya Nakarin
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Asian Pac J Cancer Prev. 2008 Jul-Sep;9(3):403-7.
To determine the clinicopathologic variables and survival in the patients with synchronous endometrial and ovarian cancer (synchronous group) compared to the patients with primary endometrial cancer with ovarian metastasis (metastatic group).
The medical records of 423 endometrial cancer patients who received primary surgery were reviewed. Fourteen patients were diagnosed as synchronous group while 49 patients were diagnosed as metastatic group.
The median age in synchronous group was significantly younger than metastatic group (47 versus 56 years). More nulliparous and premenopausal patients were demonstrated in synchronous group. Synchronous group had significantly higher incidence of low grade tumor and lower incidence of deep myometrial invasion. All patients in synchronous group presented in stage I endometrial cancer. Moreover, most patients (85.7%) presented in early stage ovarian cancer and only 14.3% in advanced stage ovarian cancer. Synchronous group had better disease free survival (DFS) and overall survival (OS) than metastatic group. Estimated 5 years DFS was 64.2% versus 41.5%, (P = 0.17) and 5 years OS was 92.8% versus 48.5% (P = 0.036).
The patients in synchronous group were younger, more nulliparous and had a better prognosis than the patients in the metastatic group.
确定同时性子宫内膜癌和卵巢癌患者（同时性组）与原发性子宫内膜癌伴卵巢转移患者（转移组）的临床病理变量及生存率。
回顾了423例行初次手术的子宫内膜癌患者的病历。14例患者被诊断为同时性组，49例患者被诊断为转移组。
同时性组的中位年龄显著低于转移组（47岁对56岁）。同时性组中未生育和绝经前患者更多。同时性组低级别肿瘤的发生率显著更高，肌层深部浸润的发生率更低。同时性组所有患者均为Ⅰ期子宫内膜癌。此外，大多数患者（85.7%）为早期卵巢癌，只有14.3%为晚期卵巢癌。同时性组的无病生存期（DFS）和总生存期（OS）均优于转移组。估计5年DFS分别为64.2%和41.5%，（P = 0.17），5年OS分别为92.8%和48.5%（P = 0.036）。
同时性组患者比转移组患者更年轻，未生育比例更高，预后更好。
