小鼠基因组序列——是尾端，还是仅仅是开端？
The mouse genome sequence--the end of the tail, or just the beginning?
作者信息
Rossant Janet, Scherer Stephen W
机构信息
Samuel Lunenfeld Research Institute, University of Toronto, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.
出版信息
Genome Biol. 2003;4(4):109. doi: 10.1186/gb-2003-4-4-109. Epub 2003 Apr 1.
Abstract
The recent flurry of papers on the mouse genome includes the description of the full genome assembly, analysis of the mouse transcriptome, the origin of interstrain variation, initial analysis of conserved non-coding regions and high-throughput expression analysis of a subset of genes. Each illustrates how the availability of the genome sequence will change the way mouse biologists do business in future.
摘要
近期关于小鼠基因组的一系列论文涵盖了全基因组组装的描述、小鼠转录组分析、品系间变异的起源、保守非编码区的初步分析以及部分基因的高通量表达分析。每一篇都展示了基因组序列的可得性将如何改变未来小鼠生物学家的研究方式。
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本文引用的文献
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Human chromosome 21 gene expression atlas in the mouse.小鼠中的人类21号染色体基因表达图谱。
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Small interfering RNA and gene silencing in transgenic mice and rats.转基因小鼠和大鼠中的小干扰RNA与基因沉默
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