V(D)J 重组中组蛋白核心和尾部的修饰
Modifications of histone cores and tails in V(D)J recombination.
作者信息
Muegge Kathrin
机构信息
Laboratory of Molecular Immunoregulation, SAIC-Basic Science Program, National Cancer Institute, Frederick, MD 21701, USA.
出版信息
Genome Biol. 2003;4(4):211. doi: 10.1186/gb-2003-4-4-211. Epub 2003 Mar 31.
Abstract
The organization of chromatin and modifications to the tails of histone proteins are thought to be important in regulating the rearrangement of V, D and J gene segments, which encode immunoglobulins and T-cell receptors. A recent study shows that methylated lysine 79 in the core region of histone H3 also plays a role by providing a euchromatic 'mark' that may regulate access of the V(D)J recombinase.
摘要
染色质的组织以及组蛋白尾部的修饰被认为在调节V、D和J基因片段的重排中起重要作用，这些基因片段编码免疫球蛋白和T细胞受体。最近的一项研究表明，组蛋白H3核心区域的赖氨酸79甲基化也发挥作用，它提供一种常染色质“标记”，可能调节V(D)J重组酶的作用。
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