Furtado D
Invest Urol. 1976 May;13(6):414-7.
In mice subcutaneous administration of the diuretics chlorothiazide or furosemide resulted in a prompt diuresis characterized by production of dilute urine within 30 min and lasting for 6 hr. In vivo proliferation or clearance of Staphylococcus aureus from the kidneys was only temporarily impaired during the time of maximum diuresis. When treatment was delayed until after phagocytosis was initiated, there was no effect on clearance. Clinically it would appear that bacterial proliferations in the renal parenchyma would not be promoted as a consequence of diuretic treatment.
在小鼠中，皮下注射利尿剂氢氯噻嗪或呋塞米会导致迅速利尿，其特征是在30分钟内产生稀释尿液，并持续6小时。在最大利尿期间，金黄色葡萄球菌在肾脏中的体内增殖或清除仅暂时受到损害。当治疗延迟到吞噬作用开始后进行时，对清除没有影响。临床上，利尿剂治疗似乎不会促进肾实质中的细菌增殖。
