De Groot C A, Tijssen A M
Arch Int Pharmacodyn Ther. 1979 Jan;237(1):75-87.
The polyuria of homozygous Brattleboro (BB) female rats is halved when they are given chlorothiazide (about 250 mg/day) or furosemide (about 60 mg/day) orally for one day. The effect of chlorothiazide is still found after 16 days of treatment, whereas the effect of furosemide entirely disappears within 5 days. Both diuretics induce chronically increased plasma renin activity (PRA) and decreased natriuresis as long as they are added to the diet; the effect on Na is more evident during furosemide treatment. Urinary urea content as well as urinary osmolality are increased by chlorothiazide and "free water" output is normalized. Furosemide does not affect urea content and decreases urinary osmolality from the start, as compared to untreated BB homozygotes; it raises "free water" output above BB values.
给纯合的布拉特伯勒（BB）雌性大鼠口服氯噻嗪（约250毫克/天）或呋塞米（约60毫克/天）一天后，其多尿症状可减轻一半。治疗16天后仍可发现氯噻嗪的作用，而呋塞米的作用在5天内完全消失。只要将这两种利尿剂添加到饮食中，它们都会使血浆肾素活性（PRA）长期升高，并减少尿钠排泄；在使用呋塞米治疗期间，对钠的影响更为明显。氯噻嗪可增加尿尿素含量和尿渗透压，并使“自由水”排出量恢复正常。与未治疗的BB纯合子相比，呋塞米从一开始就不影响尿素含量，反而降低尿渗透压；它使“自由水”排出量高于BB值。
