Parth K, Brunel R, Zimprich H, Holzer H
Helv Paediatr Acta. 1976 Apr;30(6):487-93.
According to a radioimmunological method modified in our laboratory we determined plasma aldosterone levels under standardized conditions in children of different age from 2 weeks to 14 years, in women undergoing uncomplicated vaginal delivery, and in the cord blood of the corresponding newborn babies. Furthermore, the effect of different stimulating factors (ACTH, salt restriction, severe vomiting, fever) in children was studied. In mothers and cord blood we found 68.6 +/- 39.3 ng/100 ml and 75.5 +/- 37.4 ng/100 ml, respectively. In the first two years of life there is a decrease in plasma aldosterone levels to the relatively constant concentration at the age of 2 to 14 years (7.3 +/- 4.7 ng/100 ml). The age groups 2 weeks to 1 year, 1 to 2 years and 2 to 14 years all show significant differences. A correlation of age (first two years of life) and plasma aldosterone level could be shown (correlation coefficient -0.50 according to Pearson). The stimulation results are comparable with literature data concerning adults. The mechanism of stimulation by vomiting and fever is discussed.
根据我们实验室改良的放射免疫法，我们在标准化条件下测定了不同年龄（2周龄至14岁）儿童、未经历复杂分娩的经阴道分娩女性以及相应新生儿脐带血中的血浆醛固酮水平。此外，还研究了不同刺激因素（促肾上腺皮质激素、限盐、严重呕吐、发热）对儿童的影响。在母亲和脐带血中，我们分别发现醛固酮水平为68.6±39.3 ng/100 ml和75.5±37.4 ng/100 ml。在生命的头两年，血浆醛固酮水平下降，至2至14岁时达到相对恒定的浓度（7.3±4.7 ng/100 ml）。2周龄至1岁、1至2岁和2至14岁这几个年龄组均显示出显著差异。可以看出年龄（生命的头两年）与血浆醛固酮水平之间存在相关性（根据Pearson相关系数为-0.50）。刺激结果与有关成人的文献数据具有可比性。文中讨论了呕吐和发热的刺激机制。
