Raux-Eurin M C, Pham-Huu-Trung M T, Marrec D, Girard F
Pediatr Res. 1977 Mar;11(3 Pt 1):182-5. doi: 10.1203/00006450-197703000-00008.
The direct radioimmunoassay for plasma aldosterone (PA) set up in this laboratory has been reported elsewere. Subjects were 115 normal full term newborns and infants. During the first week of life, there was a wide dispersion in the PA levels (less than 1 - 445, n = 89), but on the whole these levels were high (greater than 6 ng/100 ml) and 35% were higher than those observed in children after stimulation (greater than 48 ng/100 ml). Furthermore, there was a negative correlation between PA values and the day of sampling (P less than 0.01). In older infants, PA values were lower and the ranges narrower. A highly significant negative correlation was found between Na:K ratios and PA levels. The mean geometrical value for PA levels was 53 ng/100 ml vs. 1.012 for Na:K mean ratio. When related to weight variations, PA values were randomly distributed. No correlation was found between PA and sodium intakes. The daily urinary excretion of tetrahydroaldosterone and 3-oxoconjugate of aldosterone were lower per se, but when related to surface area, were found to be roughly 3-fold those of control adult subjects. We conclude that in the newborn, both the production and excretion of aldosterone are different than values in the adult and that responses to the regulation factors mentioned above are decreased.
本实验室建立的血浆醛固酮（PA）直接放射免疫分析法已在其他地方报道过。研究对象为115名正常足月新生儿和婴儿。在出生后的第一周，PA水平差异很大（低于1 - 445，n = 89），但总体而言这些水平较高（大于6 ng/100 ml），且35%高于刺激后儿童的水平（大于48 ng/100 ml）。此外，PA值与采样日之间存在负相关（P小于0.01）。在较大婴儿中，PA值较低且范围较窄。发现钠钾比与PA水平之间存在高度显著的负相关。PA水平的几何平均值为53 ng/100 ml，而钠钾平均比为1.012。当与体重变化相关时，PA值呈随机分布。未发现PA与钠摄入量之间存在相关性。四氢醛固酮和醛固酮3 - 氧代共轭物的每日尿排泄量本身较低，但与体表面积相关时，发现约为对照成年受试者的3倍。我们得出结论，新生儿醛固酮的产生和排泄均与成年人不同，且对上述调节因子的反应减弱。
