非地方性疟疾感染发作期间Vγ9Vδ2 T细胞无反应性及互补决定区3特异性耗竭
V gamma 9V delta 2 T-cell anergy and complementarity-determining region 3-specific depletion during paroxysm of nonendemic malaria infection.
作者信息
Martini Federico, Paglia Maria Grazia, Montesano Carla, Enders Patrick J, Gentile Marco, Pauza C David, Gioia Cristiana, Colizzi Vittorio, Narciso Pasquale, Pucillo Leopoldo Paolo, Poccia Fabrizio
机构信息
Laboratory of Clinical Pathology, National Institute for Infectious Diseases Lazzaro Spallanzani I.R.C.C.S., Rome, Italy.
出版信息
Infect Immun. 2003 May;71(5):2945-9. doi: 10.1128/IAI.71.5.2945-2949.2003.
Abstract
V gamma 9V delta 2 T lymphocytes strongly respond to phosphoantigens from Plasmodium parasites. Thus, we analyzed the changes in V gamma 9V delta 2 T-cell function and repertoire during the paroxysm phase of nonendemic malaria infection. During malaria paroxysm, V gamma 9V delta 2 T cells were early activated but rapidly became anergic and finally loose J gamma 1.2 V gamma 9 complementarity-determining region 3 transcripts.
摘要
Vγ9Vδ2 T淋巴细胞对疟原虫的磷酸抗原有强烈反应。因此，我们分析了非流行地区疟疾感染发作期Vγ9Vδ2 T细胞功能和谱系的变化。在疟疾发作期间，Vγ9Vδ2 T细胞早期被激活，但很快变得无反应，并最终丢失Jγ1.2 Vγ9互补决定区3转录本。
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