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Pneumococcal serotype 19F conjugate vaccine induces cross-protective immunity to serotype 19A in a murine pneumococcal pneumonia model.在小鼠肺炎球菌肺炎模型中，肺炎球菌19F血清型结合疫苗可诱导对19A血清型的交叉保护性免疫。
Infect Immun. 2003 May;71(5):2956-9. doi: 10.1128/IAI.71.5.2956-2959.2003.
2
The impact of 10-valent and 13-valent pneumococcal conjugate vaccines on serotype 19A invasive pneumococcal disease.10价和13价肺炎球菌结合疫苗对19A血清型侵袭性肺炎球菌疾病的影响。
Expert Rev Vaccines. 2015;14(10):1359-66. doi: 10.1586/14760584.2015.1075884. Epub 2015 Aug 7.
3
Serum samples from infants vaccinated with a pneumococcal conjugate vaccine, PncT, protect mice against invasive infection caused by Streptococcus pneumoniae serotypes 6A and 6B.接种肺炎球菌结合疫苗PncT的婴儿的血清样本可保护小鼠免受6A和6B型肺炎链球菌引起的侵袭性感染。
J Infect Dis. 2001 Jan 15;183(2):253-260. doi: 10.1086/317934. Epub 2000 Dec 8.
4
Impact of the conjugation method on the immunogenicity of Streptococcus pneumoniae serotype 19F polysaccharide in conjugate vaccines.结合方法对19F型肺炎链球菌多糖结合疫苗免疫原性的影响。
Clin Vaccine Immunol. 2011 Feb;18(2):327-36. doi: 10.1128/CVI.00402-10. Epub 2010 Dec 1.
5
Immunity to cross-reactive serotypes induced by pneumococcal conjugate vaccines in infants.婴儿肺炎球菌结合疫苗诱导的对交叉反应血清型的免疫
J Infect Dis. 1999 Nov;180(5):1569-76. doi: 10.1086/315096.
6
Pediatric Complicated Pneumonia Caused by Streptococcus pneumoniae Serotype 3 in 13-Valent Pneumococcal Conjugate Vaccinees, Portugal, 2010-2015.葡萄牙 2010-2015 年 13 价肺炎球菌结合疫苗接种者中由 3 型肺炎链球菌引起的儿童复杂性肺炎。
Emerg Infect Dis. 2018 Jul;24(7):1307-1314. doi: 10.3201/eid2407.180029.
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IgG antibody concentrations after immunization with 11-valent mixed-carrier pneumococcal conjugate vaccine in efficacy trial against pneumonia among Filipino infants.在菲律宾婴儿肺炎疗效试验中，11价混合载体肺炎球菌结合疫苗免疫后的IgG抗体浓度。
Vaccine. 2009 May 5;27(20):2680-8. doi: 10.1016/j.vaccine.2009.02.059. Epub 2009 Feb 24.
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Immunization of female mice with glycoconjugates protects their offspring against encapsulated bacteria.用糖缀合物对雌性小鼠进行免疫可保护其后代免受包膜细菌的侵害。
Infect Immun. 2004 Jan;72(1):187-95. doi: 10.1128/IAI.72.1.187-195.2004.
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Pneumococcal serotype distribution in adults with invasive disease and in carrier children in Italy: Should we expect herd protection of adults through infants' vaccination?意大利侵袭性疾病成人患者及携带肺炎球菌儿童的血清型分布：我们是否应期待通过婴儿疫苗接种实现成人的群体保护？
Hum Vaccin Immunother. 2016;12(2):344-50. doi: 10.1080/21645515.2015.1102811.
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Do pneumococcal conjugate vaccines provide any cross-protection against serotype 19A?肺炎球菌结合疫苗对 19A 血清型是否提供任何交叉保护作用？
BMC Pediatr. 2010 Feb 2;10:4. doi: 10.1186/1471-2431-10-4.

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1
Real-World Impact of Pneumococcal Conjugate Vaccines on Vaccine Serotypes and Potential Cross-Reacting Non-Vaccine Serotypes.肺炎球菌结合疫苗对疫苗血清型及潜在交叉反应性非疫苗血清型的真实世界影响
Vaccines (Basel). 2025 Jun 17;13(6):651. doi: 10.3390/vaccines13060651.
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Serotype distribution of invasive, non-invasive and carried Streptococcus pneumoniae in Malaysia: a meta-analysis.马来西亚侵袭性、非侵袭性及携带的肺炎链球菌血清型分布：一项荟萃分析
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Polysaccharide Capsule Composition of Pneumococcal Serotype 19A Subtypes Is Unaltered among Subtypes and Independent of the Nutritional Environment.肺炎球菌19A血清型各亚型的多糖荚膜成分在各亚型间未发生改变，且与营养环境无关。
Infect Immun. 2016 Oct 17;84(11):3152-3160. doi: 10.1128/IAI.00474-16. Print 2016 Nov.
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5
Immune response to 19A serotype after immunization of 19F containing pneumococcal conjugate vaccine in Korean children aged 12-23 months.12至23个月大韩国儿童接种含19F型肺炎球菌结合疫苗后对19A血清型的免疫反应
Korean J Pediatr. 2011 Apr;54(4):163-8. doi: 10.3345/kjp.2011.54.4.163. Epub 2011 Apr 30.
6
Do pneumococcal conjugate vaccines provide any cross-protection against serotype 19A?肺炎球菌结合疫苗对 19A 血清型是否提供任何交叉保护作用？
BMC Pediatr. 2010 Feb 2;10:4. doi: 10.1186/1471-2431-10-4.
7
Immune response in infants to the heptavalent pneumococcal conjugate vaccine against vaccine-related serotypes 6A and 19A.婴儿对七价肺炎球菌结合疫苗针对疫苗相关血清型6A和19A的免疫反应。
Clin Vaccine Immunol. 2009 Mar;16(3):376-81. doi: 10.1128/CVI.00344-08. Epub 2009 Jan 14.
8
Protective levels of polysaccharide-specific maternal antibodies may enhance the immune response elicited by pneumococcal conjugates in neonatal and infant mice.多糖特异性母体抗体的保护水平可能会增强新生和幼年小鼠中肺炎球菌结合疫苗引发的免疫反应。
Infect Immun. 2005 Feb;73(2):956-64. doi: 10.1128/IAI.73.2.956-964.2005.
9
Immunization of female mice with glycoconjugates protects their offspring against encapsulated bacteria.用糖缀合物对雌性小鼠进行免疫可保护其后代免受包膜细菌的侵害。
Infect Immun. 2004 Jan;72(1):187-95. doi: 10.1128/IAI.72.1.187-195.2004.

本文引用的文献

1
Immune response to octavalent diphtheria- and tetanus-conjugated pneumococcal vaccines is serotype- and carrier-specific: the choice for a mixed carrier vaccine.对八价白喉和破伤风结合肺炎球菌疫苗的免疫反应具有血清型和载体特异性：混合载体疫苗的选择
Pediatr Infect Dis J. 2002 Jun;21(6):548-54. doi: 10.1097/00006454-200206000-00013.
2
Intranasal immunization with pneumococcal conjugate vaccines with LT-K63, a nontoxic mutant of heat-Labile enterotoxin, as adjuvant rapidly induces protective immunity against lethal pneumococcal infections in neonatal mice.用肺炎球菌结合疫苗经鼻免疫新生小鼠，以不耐热肠毒素的无毒突变体LT-K63作为佐剂，可迅速诱导对致死性肺炎球菌感染的保护性免疫。
Infect Immun. 2002 Mar;70(3):1443-52. doi: 10.1128/IAI.70.3.1443-1452.2002.
3
Cross-reactivity of antibodies to type 6B and 6A polysaccharides of Streptococcus pneumoniae, evoked by pneumococcal conjugate vaccines, in infants.婴儿中肺炎球菌结合疫苗诱发的针对肺炎链球菌6B型和6A型多糖的抗体交叉反应性。
J Infect Dis. 2001 Sep 15;184(6):789-93. doi: 10.1086/322984. Epub 2001 Aug 14.
4
Characterization of the antibody response to pneumococcal glycoconjugates and the effect of heat-labile enterotoxin on IGg subclasses after intranasal immunization.鼻内免疫后对肺炎球菌糖缀合物的抗体反应特征以及不耐热肠毒素对IgG亚类的影响。
J Infect Dis. 2001 May 15;183(10):1494-500. doi: 10.1086/320202. Epub 2001 Apr 16.
5
Efficacy of a pneumococcal conjugate vaccine against acute otitis media.肺炎球菌结合疫苗对急性中耳炎的疗效。
N Engl J Med. 2001 Feb 8;344(6):403-9. doi: 10.1056/NEJM200102083440602.
6
Serum samples from infants vaccinated with a pneumococcal conjugate vaccine, PncT, protect mice against invasive infection caused by Streptococcus pneumoniae serotypes 6A and 6B.接种肺炎球菌结合疫苗PncT的婴儿的血清样本可保护小鼠免受6A和6B型肺炎链球菌引起的侵袭性感染。
J Infect Dis. 2001 Jan 15;183(2):253-260. doi: 10.1086/317934. Epub 2000 Dec 8.
7
Pneumococcal pneumonia and bacteremia model in mice for the analysis of protective antibodies.用于分析保护性抗体的小鼠肺炎球菌肺炎和菌血症模型
Microb Pathog. 2000 Aug;29(2):81-91. doi: 10.1006/mpat.2000.0363.
8
Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group.七价肺炎球菌结合疫苗在儿童中的有效性、安全性及免疫原性。北加利福尼亚凯撒医疗集团疫苗研究中心团队
Pediatr Infect Dis J. 2000 Mar;19(3):187-95. doi: 10.1097/00006454-200003000-00003.
9
The contribution of specific pneumococcal serogroups to different disease manifestations: implications for conjugate vaccine formulation and use, part II.特定肺炎球菌血清型对不同疾病表现的贡献：对结合疫苗配方和使用的影响，第二部分
Clin Infect Dis. 2000 Jan;30(1):122-40. doi: 10.1086/313609.
10
Which pneumococcal serogroups cause the most invasive disease: implications for conjugate vaccine formulation and use, part I.哪些肺炎球菌血清型导致的侵袭性疾病最多：对结合疫苗配方和使用的影响，第一部分
Clin Infect Dis. 2000 Jan;30(1):100-21. doi: 10.1086/313608.

在小鼠肺炎球菌肺炎模型中，肺炎球菌19F血清型结合疫苗可诱导对19A血清型的交叉保护性免疫。

Pneumococcal serotype 19F conjugate vaccine induces cross-protective immunity to serotype 19A in a murine pneumococcal pneumonia model.

作者信息

Jakobsen Håvard, Sigurdsson Viktor D, Sigurdardottir Sigurveig, Schulz Dominique, Jonsdottir Ingileif

机构信息

Department of Immunology, Landspitali-University Hospital, Reykjavik, Iceland.

出版信息

Infect Immun. 2003 May;71(5):2956-9. doi: 10.1128/IAI.71.5.2956-2959.2003.

DOI:10.1128/IAI.71.5.2956-2959.2003
PMID:12704178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC153277/
Abstract

Immunization with a pneumococcal conjugate vaccine (PNC) containing serotype 19F induces cross-reactive antibodies to 19A in mice and human infants. Active immunization with PNC and passive immunization with serum samples from infants vaccinated with PNC containing serotype 19F, but not serotype 19A, protected against lung infection caused by both serotypes in a murine model.

摘要

用含19F血清型的肺炎球菌结合疫苗（PNC）进行免疫接种可在小鼠和人类婴儿中诱导产生针对19A的交叉反应性抗体。在小鼠模型中，用PNC进行主动免疫以及用来自接种含19F血清型而非19A血清型PNC的婴儿的血清样本进行被动免疫，均可预防由这两种血清型引起的肺部感染。