在小鼠肺炎球菌肺炎模型中，肺炎球菌19F血清型结合疫苗可诱导对19A血清型的交叉保护性免疫。
Pneumococcal serotype 19F conjugate vaccine induces cross-protective immunity to serotype 19A in a murine pneumococcal pneumonia model.
作者信息
Jakobsen Håvard, Sigurdsson Viktor D, Sigurdardottir Sigurveig, Schulz Dominique, Jonsdottir Ingileif
机构信息
Department of Immunology, Landspitali-University Hospital, Reykjavik, Iceland.
出版信息
Infect Immun. 2003 May;71(5):2956-9. doi: 10.1128/IAI.71.5.2956-2959.2003.
Abstract
Immunization with a pneumococcal conjugate vaccine (PNC) containing serotype 19F induces cross-reactive antibodies to 19A in mice and human infants. Active immunization with PNC and passive immunization with serum samples from infants vaccinated with PNC containing serotype 19F, but not serotype 19A, protected against lung infection caused by both serotypes in a murine model.
摘要
用含19F血清型的肺炎球菌结合疫苗（PNC）进行免疫接种可在小鼠和人类婴儿中诱导产生针对19A的交叉反应性抗体。在小鼠模型中，用PNC进行主动免疫以及用来自接种含19F血清型而非19A血清型PNC的婴儿的血清样本进行被动免疫，均可预防由这两种血清型引起的肺部感染。
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