由伯克霍尔德菌属类鼻疽杆菌鼠李糖脂诱导的细胞结构和功能变化。
Structural and functional cellular changes induced by Burkholderia pseudomallei rhamnolipid.
作者信息
Häussler S, Rohde M, von Neuhoff N, Nimtz M, Steinmetz I
机构信息
Institute of Medical Microbiology. Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover. German Research Centre for Biotechnology, Braunschweig, Germany.
出版信息
Infect Immun. 2003 May;71(5):2970-5. doi: 10.1128/IAI.71.5.2970-2975.2003.
Abstract
In this study we report that extracellular Burkholderia pseudomallei rhamnolipid induced cytopathic changes characterized by retraction, rounding up, and, finally, detachment in phagocytic and nonphagocytic cell lines. These changes were due to a progressive reorganization of the F-actin network resulting in impaired cell cycle progression and a reduced phagocytic function of macrophages.
摘要
在本研究中，我们报告细胞外伯克霍尔德菌属类鼻疽杆菌鼠李糖脂可诱导细胞病变变化，其特征为吞噬细胞和非吞噬细胞系发生收缩、变圆，最终脱离。这些变化是由于F-肌动蛋白网络的逐步重组导致细胞周期进程受损以及巨噬细胞吞噬功能降低所致。
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