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1
A Burkholderia pseudomallei type III secreted protein, BopE, facilitates bacterial invasion of epithelial cells and exhibits guanine nucleotide exchange factor activity.一种伯克霍尔德菌Ⅲ型分泌蛋白BopE，可促进细菌侵袭上皮细胞并具有鸟嘌呤核苷酸交换因子活性。
J Bacteriol. 2003 Aug;185(16):4992-6. doi: 10.1128/JB.185.16.4992-4996.2003.
2
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3
Biophysical characterization of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei.伯克霍尔德菌属类鼻疽杆菌鸟嘌呤核苷酸交换因子BopE催化结构域的生物物理特性
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5
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本文引用的文献

1
Molecular pathogenesis of Salmonella enterica serotype typhimurium-induced diarrhea.鼠伤寒沙门氏菌诱导腹泻的分子发病机制。
Infect Immun. 2003 Jan;71(1):1-12. doi: 10.1128/IAI.71.1.1-12.2003.
2
Phage mediated horizontal transfer of the sopE1 gene increases enteropathogenicity of Salmonella enterica serotype Typhimurium for calves.噬菌体介导的sopE1基因水平转移增加了肠炎沙门氏菌鼠伤寒血清型对犊牛的肠道致病性。
FEMS Microbiol Lett. 2002 Dec 17;217(2):243-7. doi: 10.1111/j.1574-6968.2002.tb11482.x.
3
Characterization of the interactions between the small GTPase RhoA and its guanine nucleotide exchange factors.小GTP酶RhoA与其鸟嘌呤核苷酸交换因子之间相互作用的表征
Anal Biochem. 2002 Nov 15;310(2):156-62. doi: 10.1016/s0003-2697(02)00382-2.
4
An Inv/Mxi-Spa-like type III protein secretion system in Burkholderia pseudomallei modulates intracellular behaviour of the pathogen.类鼻疽伯克霍尔德菌中一种类似Inv/Mxi-Spa的III型蛋白分泌系统调节该病原体的细胞内行为。
Mol Microbiol. 2002 Nov;46(3):649-59. doi: 10.1046/j.1365-2958.2002.03190.x.
5
Distribution of type III secretion gene clusters in Burkholderia pseudomallei, B. thailandensis and B. mallei.III型分泌基因簇在类鼻疽伯克霍尔德菌、泰国伯克霍尔德菌和鼻疽伯克霍尔德菌中的分布。
J Med Microbiol. 2002 May;51(5):374-384. doi: 10.1099/0022-1317-51-5-374.
6
Salmonella entry into host cells: the work in concert of type III secreted effector proteins.沙门氏菌进入宿主细胞：III型分泌效应蛋白的协同作用
Microbes Infect. 2001 Nov-Dec;3(14-15):1293-8. doi: 10.1016/s1286-4579(01)01489-7.
7
A second type III secretion system in Burkholderia pseudomallei: who is the real culprit?
Microbiology (Reading). 2001 Dec;147(Pt 12):3197-9. doi: 10.1099/00221287-147-12-3197.
8
Salmonella interactions with host cells: type III secretion at work.沙门氏菌与宿主细胞的相互作用：发挥作用的III型分泌系统
Annu Rev Cell Dev Biol. 2001;17:53-86. doi: 10.1146/annurev.cellbio.17.1.53.
9
SopE and SopE2 from Salmonella typhimurium activate different sets of RhoGTPases of the host cell.鼠伤寒沙门氏菌的SopE和SopE2激活宿主细胞中不同组别的RhoGTP酶。
J Biol Chem. 2001 Sep 7;276(36):34035-40. doi: 10.1074/jbc.M100609200. Epub 2001 Jul 5.
10
SopE acts as an Rab5-specific nucleotide exchange factor and recruits non-prenylated Rab5 on Salmonella-containing phagosomes to promote fusion with early endosomes.SopE作为一种Rab5特异性核苷酸交换因子，在含沙门氏菌的吞噬体上募集未被异戊二烯化的Rab5，以促进其与早期内体融合。
J Biol Chem. 2001 Jun 29;276(26):23607-15. doi: 10.1074/jbc.M101034200. Epub 2001 Apr 20.

一种伯克霍尔德菌Ⅲ型分泌蛋白BopE，可促进细菌侵袭上皮细胞并具有鸟嘌呤核苷酸交换因子活性。

A Burkholderia pseudomallei type III secreted protein, BopE, facilitates bacterial invasion of epithelial cells and exhibits guanine nucleotide exchange factor activity.

作者信息

Stevens Mark P, Friebel Andrea, Taylor Lowrie A, Wood Michael W, Brown Philip J, Hardt Wolf-Dietrich, Galyov Edouard E

机构信息

Division of Environmental Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire RG20 7NN, United Kingdom.

出版信息

J Bacteriol. 2003 Aug;185(16):4992-6. doi: 10.1128/JB.185.16.4992-4996.2003.

DOI:10.1128/JB.185.16.4992-4996.2003
PMID:12897019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC166480/
Abstract

We report the characterization of BopE, a type III secreted protein that is encoded adjacent to the Burkholderia pseudomallei bsa locus and is homologous to Salmonella enterica SopE/SopE2. Inactivation of bopE impaired bacterial entry into HeLa cells, indicating that BopE facilitates invasion. Consistent with this notion, BopE expressed in eukaryotic cells induced rearrangements in the subcortical actin cytoskeleton, and purified BopE exhibited guanine nucleotide exchange factor activity for Cdc42 and Rac1 in vitro.

摘要

我们报告了对BopE的特性描述，BopE是一种III型分泌蛋白，其编码基因位于类鼻疽伯克霍尔德菌bsa基因座附近，与肠炎沙门氏菌SopE/SopE2同源。bopE基因的失活损害了细菌进入HeLa细胞的能力，表明BopE促进了细菌的入侵。与此观点一致的是，在真核细胞中表达的BopE诱导了皮层下肌动蛋白细胞骨架的重排，并且纯化的BopE在体外对Cdc42和Rac1表现出鸟嘌呤核苷酸交换因子活性。