Jubinsky Paul T, Short Mary K, Mutema George, Witte David P
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
J Histochem Cytochem. 2003 May;51(5):585-96. doi: 10.1177/002215540305100504.
Magmas is a protein that is involved in GM-CSF signaling in a myeloid cell line. Its precise role in the signal transduction process is unclear. To accurately characterize Magmas expression in a variety of cells, mouse embryos and adult murine tissues were analyzed for both mRNA and protein content. Magmas expression was detected as early as the day 6.5 embryo. The level of expression was developmentally regulated. During embryogenesis, elevated Magmas was observed in several structures, including heart, liver, notochord, choroid plexus, cervical ganglion, and nasal mucosa. Muscle, pancreas, intestinal mucosa, and testes were among the adult tissues with high Magmas expression. Most cell types, including hepatocytes and skeletal, smooth, and cardiac myocytes, also expressed the GM-CSF receptor (GMR) but the relative tissue levels of GMR were not always proportional to Magmas. The expression patterns suggest that Magmas has a role in both developing and mature tissues.
Magmas是一种参与髓系细胞系中GM-CSF信号传导的蛋白质。其在信号转导过程中的精确作用尚不清楚。为了准确表征Magmas在多种细胞中的表达情况，对小鼠胚胎和成年鼠组织的mRNA和蛋白质含量进行了分析。早在胚胎第6.5天就检测到了Magmas的表达。表达水平受发育调控。在胚胎发生过程中，在几个结构中观察到Magmas水平升高，包括心脏、肝脏、脊索、脉络丛、颈神经节和鼻粘膜。肌肉、胰腺、肠粘膜和睾丸是Magmas表达较高的成年组织。大多数细胞类型，包括肝细胞以及骨骼肌、平滑肌和心肌细胞，也表达GM-CSF受体（GMR），但GMR的相对组织水平并不总是与Magmas成比例。表达模式表明Magmas在发育中和成熟组织中均发挥作用。
