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Nitroxyl gets to the heart of the matter.硝酰自由基抓住了问题的关键。
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):4978-80. doi: 10.1073/pnas.1031571100. Epub 2003 Apr 18.
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The failing human heart does not release nitrogen oxides.
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Examining nitroxyl in biological systems.研究生物系统中的硝酰基。
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The chemistry and biology of nitroxyl (HNO): a chemically unique species with novel and important biological activity.硝酰基（HNO）的化学与生物学：一种具有新颖且重要生物活性的化学独特物种。
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Mechanistic Origin of Favorable Substituent Effects in Excellent Cu Cyclam Based HNO Sensors.优异的铜环脒基 HNO 传感器中有利取代基效应的机制起源。
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The fluorescence regulation mechanism of the paramagnetic metal in a biological HNO sensor.生物型HNO传感器中顺磁性金属的荧光调控机制
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Chemotherapeutic potential of diazeniumdiolate-based aspirin prodrugs in breast cancer.基于二氮烯二醇盐的阿司匹林前药在乳腺癌中的化疗潜力。
Free Radic Biol Med. 2015 Jun;83:101-14. doi: 10.1016/j.freeradbiomed.2015.01.029. Epub 2015 Feb 4.

本文引用的文献

1
Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from beta-adrenergic signaling.HNO/NO⁻对衰竭心脏的正性肌力和变时性作用：独立于β-肾上腺素能信号传导
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5537-42. doi: 10.1073/pnas.0937302100. Epub 2003 Apr 18.
2
Nitroxyl-mediated disruption of thiol proteins: inhibition of the yeast transcription factor Ace1.硝酰介导的硫醇蛋白破坏：对酵母转录因子Ace1的抑制作用
Arch Biochem Biophys. 2003 Feb 1;410(1):89-95. doi: 10.1016/s0003-9861(02)00656-2.
3
Treatment of heart failure through stabilization of the cardiac ryanodine receptor.通过稳定心肌兰尼碱受体治疗心力衰竭。
Circulation. 2003 Jan 28;107(3):378-80. doi: 10.1161/01.cir.0000046342.46135.cb.
4
Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS.一氧化氮和硝酰基与血红素蛋白反应性的比较。对一氧化氮合酶这些氧化还原相关产物的不同生物学效应的化学探讨。
J Inorg Biochem. 2003 Jan 1;93(1-2):52-60. doi: 10.1016/s0162-0134(02)00498-1.
5
The reduction potential of nitric oxide (NO) and its importance to NO biochemistry.一氧化氮（NO）的还原电位及其在NO生物化学中的重要性。
Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):10958-63. doi: 10.1073/pnas.162095599. Epub 2002 Aug 12.
6
Oxidative stress and endothelial dysfunction in heart failure.心力衰竭中的氧化应激与内皮功能障碍。
Congest Heart Fail. 2002 May-Jun;8(3):165-72. doi: 10.1111/j.1527-5299.2002.00714.x.
7
Levosimendan: a new era for inodilator therapy for heart failure?左西孟旦：心力衰竭的血管扩张剂治疗新时代？
Curr Opin Cardiol. 2002 May;17(3):257-65. doi: 10.1097/00001573-200205000-00008.
8
New therapeutic options in congestive heart failure: Part I.充血性心力衰竭的新治疗选择：第一部分。
Circulation. 2002 Apr 30;105(17):2099-106. doi: 10.1161/01.cir.0000014763.63528.9d.
9
Medical management of advanced heart failure.晚期心力衰竭的药物治疗
JAMA. 2002 Feb 6;287(5):628-40. doi: 10.1001/jama.287.5.628.
10
ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to revise the 1995 Guidelines for the Evaluation and Management of Heart Failure).美国心脏病学会/美国心脏协会成人慢性心力衰竭评估与管理指南：执行摘要。美国心脏病学会/美国心脏协会实践指南工作组（修订1995年心力衰竭评估与管理指南委员会）报告。
J Am Coll Cardiol. 2001 Dec;38(7):2101-13. doi: 10.1016/s0735-1097(01)01683-7.

Nitroxyl gets to the heart of the matter.

作者信息

Feelisch Martin

机构信息

Louisiana State University Health Sciences Center, Department of Molecular and Cellular Physiology, 1501 Kings Highway, Shreveport, LA 71130, USA.

出版信息

Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):4978-80. doi: 10.1073/pnas.1031571100. Epub 2003 Apr 18.

DOI:10.1073/pnas.1031571100
PMID:12704227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC154282/
Abstract
摘要