Binstadt Bryce A, Geha Raif S, Bonilla Francisco A
Division of Immunology, Children's Hospital Boston, MA 02115, USA.
J Allergy Clin Immunol. 2003 Apr;111(4):697-703. doi: 10.1067/mai.2003.1380.
Polymorphisms of human Fc receptors (FcRs) have been described that are associated with the development or progression of autoimmune diseases. The FcR polymorphisms affect the affinity with which FcRs interact with immunoglobulin molecules. Intravenous immunoglobulin is administered as therapy for many autoimmune diseases and might exert its effects by interacting with FcRs. Thus, FcR polymorphisms might influence the efficacy of intravenous immunoglobulin therapy for patients with certain autoimmune diseases. In this article we review FcR polymorphisms in relation to autoimmune diseases for which intravenous immunoglobulin is used therapeutically.
已有研究描述了人类Fc受体（FcRs）的多态性与自身免疫性疾病的发生或进展相关。FcR多态性影响FcRs与免疫球蛋白分子相互作用的亲和力。静脉注射免疫球蛋白被用作多种自身免疫性疾病的治疗方法，可能通过与FcRs相互作用发挥其作用。因此，FcR多态性可能会影响静脉注射免疫球蛋白对某些自身免疫性疾病患者的治疗效果。在本文中，我们综述了与静脉注射免疫球蛋白用于治疗的自身免疫性疾病相关的FcR多态性。
