Yan Mengyao, Wang Zhe, Qiu Zhiwei, Cui Yimin, Xiang Qian
Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China.
Biomark Res. 2024 Dec 31;12(1):164. doi: 10.1186/s40364-024-00700-y.
Platelets are essential for blood clotting and maintaining normal hemostasis. In pathological conditions, platelets are increasingly recognized as crucial regulatory factors in various immune-mediated inflammatory diseases. Resting platelets are induced by various factors such as immune complexes through Fc receptors, platelet-targeting autoantibodies and other platelet-activating stimuli. Platelet activation in immunological processes involves the release of immune activation stimuli, antigen presentation and interaction with immune cells. Platelets participate in both the innate immune system (neutrophils, monocytes/macrophages, dendritic cells (DCs) and Natural Killer (NK) cells and the adaptive immune system (T and B cells). Clinical therapeutic strategies include targeting platelet activation, platelet-immune cell interaction and platelet-endothelial cell interaction, which display positive development prospects. Understanding the mechanisms of platelets in immunity is important, and developing targeted modulations of these mechanisms will pave the way for promising therapeutic strategies.
血小板对于血液凝固和维持正常止血至关重要。在病理状态下，血小板在各种免疫介导的炎症性疾病中日益被视为关键的调节因子。静息血小板可被多种因素诱导，如通过Fc受体的免疫复合物、靶向血小板的自身抗体以及其他血小板激活刺激物。免疫过程中的血小板激活涉及免疫激活刺激物的释放、抗原呈递以及与免疫细胞的相互作用。血小板参与固有免疫系统（中性粒细胞、单核细胞/巨噬细胞、树突状细胞（DCs）和自然杀伤（NK）细胞）和适应性免疫系统（T细胞和B细胞）。临床治疗策略包括靶向血小板激活、血小板-免疫细胞相互作用和血小板-内皮细胞相互作用，这些策略展现出良好的发展前景。了解血小板在免疫中的机制很重要，开发针对这些机制的靶向调节方法将为有前景的治疗策略铺平道路。
